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Renal and hepatic function of patients with severe tricuspid regurgitation undergoing inferior caval valve implantation
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Renal and hepatic function of patients with severe tricuspid regurgitation undergoing inferior caval valve implantation
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Journal Article
Renal and hepatic function of patients with severe tricuspid regurgitation undergoing inferior caval valve implantation
2021
Overview
Due to progressive abdominal-venous congestion severe tricuspid regurgitation (TR) is a common cause of cardiorenal and cardiohepatic syndrome. We initiated the TRICAVAL study to compare interventional valve implantation into the inferior vena cava (CAVI) versus optimal medical therapy (OMT) in severe TR. In the present subanalysis, we aimed to evaluate the effects of CAVI on clinical signs of congestion, renal and hepatic function. TRICAVAL was an investigator-initiated, randomized trial. Twenty-eight patients with severe TR were randomized to OMT or CAVI using an Edwards Sapien XT valve. Probands who completed the 3-month follow-up (CAVI [
n
= 8], OMT [
n
= 10]) were evaluated by medical history, clinical examination, and laboratory testing at baseline, 3 and 12 months. After 3 months, the CAVI group exhibited a significant reduction of body weight (from 80.7 [69.0–87.7] kg to 75.5 [63.8–84.6] kg,
p
< 0.05) and abdominal circumference (from 101.5 ± 13.8 cm to 96.3 ± 15.4 cm,
p
≤ 0.01) and a trend to lower doses of diuretics compared to OMT. Renal and hepatic function parameters did not change significantly. Within a short-term follow-up, CAVI led to an improvement of clinical signs of venous congestion and a non-significant reduction of diuretic doses compared to OMT.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
