Journal Article

The gut microbiome and early-life growth in a population with high prevalence of stunting

Edens, Thaddeus J., Manges, Amee R., Gough, Ethan K., Smith, Laura E., Carr, Lynnea, Francis, Freddy, Robertson, Ruairi C., Tome, Joice, Evans, Ceri, Chasekwa, Bernard, Baharmand, Iman, Tavengwa, Naume V., Majo, Florence D., Mutasa, Batsirai, Prendergast, Andrew J., Mutasa, Kuda, Gill, Sandeep K., Humphrey, Jean H., Stoltzfus, Rebecca J., Geum, Hyun Min, Ntozini, Robert

2023

Overview

Stunting affects one-in-five children globally and is associated with greater infectious morbidity, mortality and neurodevelopmental deficits. Recent evidence suggests that the early-life gut microbiome affects child growth through immune, metabolic and endocrine pathways. Using whole metagenomic sequencing, we map the assembly of the gut microbiome in 335 children from rural Zimbabwe from 1–18 months of age who were enrolled in the Sanitation, Hygiene, Infant Nutrition Efficacy Trial (SHINE; NCT01824940), a randomized trial of improved water, sanitation and hygiene (WASH) and infant and young child feeding (IYCF). Here, we show that the early-life gut microbiome undergoes programmed assembly that is unresponsive to the randomized interventions intended to improve linear growth. However, maternal HIV infection is associated with over-diversification and over-maturity of the early-life gut microbiome in their uninfected children, in addition to reduced abundance of Bifidobacterium species. Using machine learning models (XGBoost), we show that taxonomic microbiome features are poorly predictive of child growth, however functional metagenomic features, particularly B-vitamin and nucleotide biosynthesis pathways, moderately predict both attained linear and ponderal growth and growth velocity. New approaches targeting the gut microbiome in early childhood may complement efforts to combat child undernutrition. Here, using metagenomics, the authors show that the gut microbiome of rural Zimbabwean infants undergoes programmed maturation that is unresponsive to sanitation and nutrition interventions but is strongly associated with maternal HIV infection and can moderately predict linear growth.

• Publisher: Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
• Subject: 45 / 45/22 / 45/23 / 631/326/2565/2134 / 692/4020/1503/1702/295 / Assembly / Biosynthesis / Child / Child, Preschool / Children / Children & youth / Digestive system / Gastrointestinal Microbiome - genetics / Growth Disorders - epidemiology / Gut microbiota / HIV / HIV Infections / Human immunodeficiency virus / Human nutrition / Humanities and Social Sciences / Humans / Hygiene / Infant / Infant nutrition / Infants / Intestinal microflora / Machine learning / Malnutrition / Metagenomics / Microbiomes / Microbiota / Morbidity / multidisciplinary / Nucleotides / Prevalence / Sanitation / Science / Science (multidisciplinary) / Undernutrition / Water Supply