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Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk
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Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk
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Journal Article
Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk
2024
Overview
In mice, periodic cycles of a fasting mimicking diet (FMD) protect normal cells while killing damaged cells including cancer and autoimmune cells, reduce inflammation, promote multi-system regeneration, and extend longevity. Here, we performed secondary and exploratory analysis of blood samples from a randomized clinical trial (NCT02158897) and show that 3 FMD cycles in adult study participants are associated with reduced insulin resistance and other pre-diabetes markers, lower hepatic fat (as determined by magnetic resonance imaging) and increased lymphoid to myeloid ratio: an indicator of immune system age. Based on a validated measure of biological age predictive of morbidity and mortality, 3 FMD cycles were associated with a decrease of 2.5 years in median biological age, independent of weight loss. Nearly identical findings resulted from a second clinical study (NCT04150159). Together these results provide initial support for beneficial effects of the FMD on multiple cardiometabolic risk factors and biomarkers of biological age.
Fasting mimicking diets (FMDs) can promote healthy aging in animal models but effects on human healthspan remain elusive. Here the authors provide support for beneficial effects of the FMD on cardiometabolic risk factors and biological age biomarkers.
