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Stenting and Medical Therapy for Atherosclerotic Renal-Artery Stenosis
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Stenting and Medical Therapy for Atherosclerotic Renal-Artery Stenosis
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Journal Article
Stenting and Medical Therapy for Atherosclerotic Renal-Artery Stenosis
2014
Overview
In this trial, 947 patients with renal-artery stenosis were assigned to renal-artery stenting or medical therapy. At a median of 43 months, there was no significant between-group difference in the rate of a composite end point of adverse cardiovascular and renal events.
Renal-artery stenosis, which is present in 1 to 5% of people with hypertension,
1
,
2
often occurs in combination with peripheral arterial or coronary artery disease.
3
,
4
Results of community-based screening suggest that the prevalence among persons older than 65 years of age may be as high as 7%.
5
Renal-artery stenosis may result in hypertension, ischemic nephropathy, and multiple long-term complications.
6
Uncontrolled studies performed in the 1990s suggested that renal-artery angioplasty or stenting resulted in significant reductions in systolic blood pressure
7
,
8
and in the stabilization of chronic kidney disease.
9
,
10
Subsequently, there were rapid increases in the rate of renal-artery . . .
Publisher
Massachusetts Medical Society
Subject
/ Amlodipine - therapeutic use
/ Angiotensin II Type 1 Receptor Blockers - therapeutic use
/ Anticholesteremic Agents - therapeutic use
/ Antihypertensive Agents - therapeutic use
/ Atherosclerosis (general aspects, experimental research)
/ Biological and medical sciences
/ Cardiovascular Diseases - etiology
/ Cardiovascular Diseases - mortality
/ Female
/ Heptanoic Acids - therapeutic use
/ Humans
/ Hypertension - complications
/ Implants
/ Kidneys
/ Male
/ Nephrology. Urinary tract diseases
/ Nephropathies. Renovascular diseases. Renal failure
/ Renal Artery Obstruction - complications
/ Renal Artery Obstruction - drug therapy
/ Renal Artery Obstruction - therapy
/ Renal Insufficiency, Chronic - complications
/ Stenosis
/ Stents
/ Stroke
