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Clinical effects of methylphenidate hydrochloride extended-release tablets on improvement of intelligence and behavior in children with attention deficit hyperactivity disorder
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Clinical effects of methylphenidate hydrochloride extended-release tablets on improvement of intelligence and behavior in children with attention deficit hyperactivity disorder
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Journal Article
Clinical effects of methylphenidate hydrochloride extended-release tablets on improvement of intelligence and behavior in children with attention deficit hyperactivity disorder
2025
Overview
This study aimed to investigate the impacts of methylphenidate hydrochloride extended-release tablets on intelligence and behavior in children with attention deficit hyperactivity disorder. One hundred and twenty children with attention deficit hyperactivity disorder admitted to Nanjing First Hospital, Nanjing Medical University, Nanjing, China from January 2023 to January 2025 were included and randomly divided into a control group and a study group. The study group adopted methylphenidate hydrochloride extended-release tablets. The control group adopted placebo. Compared with the control group, the study group had an increase in intelligence level scores, self-awareness scores and quality of life scores as well as a decrease in behavior scores and clinical symptoms scores following 12 weeks of treatment. Compared with the control group, 5-hydroxytryptamine, norepinephrine and dopamine levels in the study group were higher after 12 weeks of treatment. However, the above indicators showed no differences in the control group between before and after treatment. We conclude that methylphenidate hydrochloride extended-release tablets improve the intelligence level, attention and behavior problems, promote self-awareness and quality of life, and improve the levels of monoamine neurotransmitters in children with attention deficit hyperactivity disorder.
Cette étude visait à évaluer l'impact des comprimés de chlorhydrate de méthylphénidate à libération prolongée sur l'intelligence et le comportement d'enfants atteints de trouble déficitaire de l'attention avec hyperactivité (TDAH). Cent vingt enfants atteints de TDAH, admis au Nanjing First Hospital, Université de médecine de Nanjing, en Chine, entre janvier 2023 et janvier 2025, ont été inclus et répartis aléatoirement en un groupe témoin et un groupe d'étude. Le groupe d'étude a pris des comprimés de chlorhydrate de méthylphénidate à libération prolongée. Le groupe témoin a pris un placebo. Comparativement au groupe témoin, le groupe d'étude a présenté une augmentation des scores d'intelligence, de conscience de soi et de qualité de vie, ainsi qu'une diminution des scores de comportement et des symptômes cliniques après 12 semaines de traitement. Comparativement au groupe témoin, les taux de 5-hydroxytryptamine, de noradrénaline et de dopamine étaient plus élevés après 12 semaines de traitement. Cependant, les indicateurs mentionnés ci-dessus n'ont montré aucune différence entre le groupe témoin avant et après le traitement. Nous concluons que les comprimés de chlorhydrate de méthylphénidate à libération prolongée améliorent le niveau d'intelligence, l'attention et les troubles du comportement, favorisent la conscience de soi et la qualité de vie, et améliorent les taux de neurotransmetteurs monoamines chez les enfants atteints de trouble déficitaire de l'attention avec hyperactivité.
Publisher
Women’s Health and Action Research Centre,Women's Health and Action Research Centre (WHARC),Women's Health and Action Research Centre
Subject
/ Attention Deficit Disorder with Hyperactivity - drug therapy
/ Attention Deficit Disorder with Hyperactivity - psychology
/ Attention deficit hyperactivity disorder
/ Behavior
/ Central Nervous System Stimulants - administration & dosage
/ Central Nervous System Stimulants - therapeutic use
/ Child
/ Children
/ China
/ Dopamine
/ Female
/ Humans
/ Male
/ Methylphenidate - administration & dosage
/ Methylphenidate - therapeutic use
/ Methylphenidate hydrochloride
/ methylphenidate hydrochloride prolonged-release tablet
/ Tablets
