Asset Details
Do you wish to reserve the book?
Striatal dopamine D2/D3 receptor regulation of human reward processing and behaviour
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Striatal dopamine D2/D3 receptor regulation of human reward processing and behaviour
Do you wish to request the book?
Striatal dopamine D2/D3 receptor regulation of human reward processing and behaviour
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Striatal dopamine D2/D3 receptor regulation of human reward processing and behaviour
2025
Overview
Signalling at dopamine D2/D3 receptors is thought to underlie motivated behaviour, pleasure experiences and emotional expression based on animal studies, but it is unclear if this is the case in humans or how this relates to neural processing of reward stimuli. Using a randomised, double-blind, placebo-controlled, crossover neuroimaging study, we show in healthy humans that sustained dopamine D2/D3 receptor antagonism for 7 days results in negative symptoms (impairments in motivated behaviour, hedonic experience, verbal and emotional expression) and that this is related to blunted striatal response to reward stimuli. In contrast, 7 days of partial D2/D3 agonism does not disrupt reward signalling, motivated behaviour or hedonic experience. Both D2/D3 antagonism and partial agonism induce motor impairments, which are not related to striatal reward response. These findings identify a central role for D2/D3 signalling and reward processing in the mechanism underlying motivated behaviour and emotional responses in humans, with implications for understanding neuropsychiatric disorders such as schizophrenia and Parkinson’s disease.
Osugo et al show in healthy humans that sustained dopamine D2/D3 receptor antagonism impairs motivated behaviour, hedonic experience, and emotional expression, and that this is related to blunted striatal reward response following D2/D3 antagonism.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 59/57
/ Adult
/ Corpus Striatum - diagnostic imaging
/ Corpus Striatum - drug effects
/ Corpus Striatum - metabolism
/ Corpus Striatum - physiology
/ Dopamine
/ Dopamine Antagonists - administration & dosage
/ Dopamine D2 Receptor Antagonists - administration & dosage
/ Dopamine D2 Receptor Antagonists - pharmacology
/ Female
/ Humanities and Social Sciences
/ Humans
/ Male
/ Receptors, Dopamine D2 - agonists
/ Receptors, Dopamine D2 - metabolism
/ Receptors, Dopamine D3 - agonists
/ Receptors, Dopamine D3 - antagonists & inhibitors
/ Receptors, Dopamine D3 - metabolism
/ Reward
/ Science
/ Stimuli
