Journal Article

Edema in critically ill patients leads to overestimation of skeletal muscle mass measurements using computed tomography scans

Schnabel, Ronny M., van de Poll, Marcel C.G., Baggerman, Michelle R., Bakers, Frans C., Winkens, Bjorn, van Dijk, David P.J., Bol, Martine E., Olde Damink, Steven W.M., van Gassel, Rob J.J.

2021

Overview

•The assessment of muscle loss during critical illness using computed tomography scans is hampered by the formation of edema.•Edema in critical illness leads to overestimation of muscle area measurements.•Edema formation and decreased muscle quality were associated with a higher disease severity.•Muscle radiation attenuation cannot be used as an indicator for formation of edema.•In critical illness, researchers must be careful with the interpretation of muscle area measurements. Changes in muscle mass and quality are important targets for nutritional intervention in critical illness. Effects of such interventions may be assessed using sequential computed tomography (CT) scans. However, fluid and lipid infiltration potentially affects muscle area measurements. The aim of this study was to evaluate changes in muscle mass and quality in critical illness with special emphasis on the influence of edema on this assessment. Changes in skeletal muscle area index (SMI) and radiation attenuation (RA) at the level of vertebra L3 were analyzed using sequential CT scans of 77 patients with abdominal sepsis. Additionally, the relation between these changes and disease severity using the maximum Sequential Organ Failure Assessment (SOFA) score and change in edema were studied. SMI declined on average 0.35%/d (±1.22%; P = 0.013). However, SMI increased in 41.6% of the study population. Increasing edema formation was significantly associated with increased SMI and with a higher SOFA score. Muscle RA decreased during critical illness, but was not significantly associated with changes in SMI or changes in edema. In critically ill patients, edema affects skeletal muscle area measurements, which leads to an overestimation of skeletal muscle area. A higher SOFA score was associated with edema formation. Because both edema and fat infiltration may affect muscle RA, the separate effects of these on muscle quality are difficult to distinguish. When using abdominal CT scans to changes in muscle mass and quality in critically ill patients, researchers must be aware and careful with the interpretation of the results.

• Publisher: Elsevier Inc,Elsevier Limited
• Subject: Abdomen / Attenuation / Body composition / Classification / Computed tomography / Critical illness / disease severity / Edema / Illnesses / Infiltration / Lipids / Medical imaging / Mortality / Muscle mass / Muscle quality / Muscles / Musculoskeletal system / nutrition / nutritional intervention / Patients / Population studies / Radiation / Sepsis / Skeletal muscle / Software / Spine / Tomography / Vertebrae