Journal Article

Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury

Rungratanawanich, Wiramon, Song, Byoung-Joon, Qu, Ying, Essa, Musthafa Mohamed, Wang, Xin

2021

Overview

Advanced glycation end products (AGEs) are potentially harmful and heterogeneous molecules derived from nonenzymatic glycation. The pathological implications of AGEs are ascribed to their ability to promote oxidative stress, inflammation, and apoptosis. Recent studies in basic and translational research have revealed the contributing roles of AGEs in the development and progression of various aging-related pathological conditions, such as diabetes, cardiovascular complications, gut microbiome-associated illnesses, liver or neurodegenerative diseases, and cancer. Excessive chronic and/or acute binge consumption of alcohol (ethanol), a widely consumed addictive substance, is known to cause more than 200 diseases, including alcohol use disorder (addiction), alcoholic liver disease, and brain damage. However, despite the considerable amount of research in this area, the underlying molecular mechanisms by which alcohol abuse causes cellular toxicity and organ damage remain to be further characterized. In this review, we first briefly describe the properties of AGEs: their formation, accumulation, and receptor interactions. We then focus on the causative functions of AGEs that impact various aging-related diseases. We also highlight the biological connection of AGE–alcohol–adduct formations to alcohol-mediated tissue injury. Finally, we describe the potential translational research opportunities for treatment of various AGE- and/or alcohol-related adduct-associated disorders according to the mechanistic insights presented. Metabolism: AGEs in aging- and alcohol-related diseases Advanced glycation end products (AGEs), molecules formed when proteins and lipids combine with sugar, play key roles in aging-related diseases and in alcohol-induced tissue damage. AGEs naturally accumulate in the body with aging, and are also present in food, particularly in fried and processed foods. They are also produced by alcohol metabolism and cigarette smoking. Byoung-Joon Song and Wiramon Rungratanawanich at the National Institute on Alcohol Abuse and Alcoholism in Bethesda, USA, have reviewed how AGEs accumulate and their roles in aging-related diseases and alcohol-related health effects. They report that AGEs are linked to promotion or exacerbation of many diseases such as cardiovascular and kidney disease, adult-onset diabetes, cancer, and neurodegenerative conditions like Alzheimer’s and Parkinson’s diseases. The authors highlight opportunities for further research and for reducing AGE accumulation through changes in diet and behavior.

• Publisher: Nature Publishing Group UK,Springer Nature B.V,생화학분자생물학회
• Subject: 13/2 / 692/308 / 692/308/1426 / 82/80 / Abuse / Addictions / Adducts / Advanced glycosylation end products / Aging / Aging - genetics / Aging - metabolism / Alcohol abuse / Alcoholism / Animals / Apoptosis / Biomarkers / Biomedical and Life Sciences / Biomedicine / Brain injury / Cigarette smoking / Diabetes / Diabetes mellitus / Disease Susceptibility / Drug abuse / Drug addiction / Ethanol / Ethanol - adverse effects / Ethanol - metabolism / Extracellular Space - metabolism / Food processing / Gene Expression Regulation / Glycation End Products, Advanced - genetics / Glycation End Products, Advanced - metabolism / Glycosylation / Humans / Intestinal microflora / Intracellular Space - metabolism / Kidney diseases / Lipid Peroxidation / Lipids / Liver diseases / Medical Biochemistry / Metabolism / Microbiomes / Molecular Medicine / Molecular modelling / Neurodegenerative diseases / Organ Specificity / Oxidative Stress / Processed foods / Protein Processing, Post-Translational / Receptor for Advanced Glycation End Products - genetics / Receptor for Advanced Glycation End Products - metabolism / Review / Review Article / Stem Cells / Toxicity / Translation / 생화학