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Links between fecal microbiota and the response to vaccination against influenza A virus in pigs

by Billon, Yvon , Borey, Marion , Leplat, Jean-Jacques , Bernard, Maria , Blanc, Fany , Lemonnier, Gaëtan , Rossignol, Marie-Noëlle , Jardet, Deborah , Ravon, Laure , Estellé, Jordi , Rogel-Gaillard, Claire

in 631/250/590/1883 / 631/326/41/2533 / 631/326/590 / 692/53 / 692/53/2423 / Biomedical and Life Sciences / Biomedicine / Feces / Hogs / Humanities and Social Sciences / Immune response / Infectious Diseases / Influenza / Medical Microbiology / Microbiota / Public Health / Vaccine / Vaccines / Virology

2021

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Links between fecal microbiota and the response to vaccination against influenza A virus in pigs

2021

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2021

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Journal Article

Links between fecal microbiota and the response to vaccination against influenza A virus in pigs

Billon, Yvon,

Borey, Marion,

Leplat, Jean-Jacques,

Bernard, Maria,

Blanc, Fany,

Lemonnier, Gaëtan,

Rossignol, Marie-Noëlle,

Jardet, Deborah,

Ravon, Laure,

Estellé, Jordi,

Rogel-Gaillard, Claire

2021

Overview

This study describes the associations between fecal microbiota and vaccine response variability in pigs, using 98 piglets vaccinated against the influenza A virus at 28 days of age (D28) with a booster at D49. Immune response to the vaccine is measured at D49, D56, D63, and D146 by serum levels of IAV-specific IgG and assays of hemagglutination inhibition (HAI). Analysis of the pre-vaccination microbiota characterized by 16S rRNA gene sequencing of fecal DNA reveals a higher vaccine response in piglets with a richer microbiota, and shows that 23 operational taxonomic units (OTUs) are differentially abundant between high and low IAV-specific IgG producers at D63. A stronger immune response is linked with OTUs assigned to the genus Prevotella and family Muribaculaceae, and a weaker response is linked with OTUs assigned to the genera Helicobacter and Escherichia-Shigella . A set of 81 OTUs accurately predicts IAV-specific IgG and HAI titer levels at all time points, highlighting early and late associations between pre-vaccination fecal microbiota composition and immune response to the vaccine.

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Publisher

Nature Publishing Group UK,Nature Publishing Group,Nature Research,Nature Portfolio

Subject

/ 692/53

/ Biomedical and Life Sciences

/ Biomedicine