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DGIdb: mining the druggable genome

by Wilson, Richard K , Larson, David E , Smith, Scott M , McMichael, Josh F , Das, Indraniel , Griffith, Malachi , Govindan, Ramaswamy , Coffman, Adam C , Mardis, Elaine R , Callaway, Matthew B , Spies, Nicholas C , Bose, Ron , Ley, Timothy J , Weible, James V , Walker, Jason R , Dooling, David J , Koval, James , Kumar, Runjun D , Subramanian, Janakiraman , Griffith, Obi L , Eldred, James M , Ding, Li , Miller, Christopher A

in 631/114/129 / 631/114/2164 / 631/114/2401 / 631/154 / Antineoplastic Agents - chemistry / Bioinformatics / Biological Microscopy / Biological Techniques / Biomedical Engineering/Biotechnology / Breast Neoplasms - drug therapy / Breast Neoplasms - genetics / brief-communication / Computational Biology - methods / Data Mining - methods / Databases, Genetic / Drug Discovery - methods / Drug Interactions / Drug therapy / Gene Expression Regulation - drug effects / Gene mutations / Genes / Genetic Variation / Genome / Genomes / Genomics / Genomics - methods / Humans / Information services / Life Sciences / Lung Neoplasms - drug therapy / Lung Neoplasms - genetics / Mines / Mutation / Online information services / Online services / Pharmaceutical research / Proteomics / Services / Software / Technology, Pharmaceutical - methods

2013

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DGIdb: mining the druggable genome

2013

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2013

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Journal Article

DGIdb: mining the druggable genome

Wilson, Richard K,

Larson, David E,

Smith, Scott M,

McMichael, Josh F,

Das, Indraniel,

Griffith, Malachi,

Govindan, Ramaswamy,

Coffman, Adam C,

Mardis, Elaine R,

Callaway, Matthew B,

Spies, Nicholas C,

Bose, Ron,

Ley, Timothy J,

Weible, James V,

Walker, Jason R,

Dooling, David J,

Koval, James,

Kumar, Runjun D,

Subramanian, Janakiraman,

Griffith, Obi L,

Eldred, James M,

Ding, Li,

Miller, Christopher A

2013

Overview

A database of known drug-gene interactions, with information derived from many public sources, allows the identification of genes that are currently targeted by a drug and the membership of genes in a category, such as kinase genes, that have a high potential for drug development. The Drug-Gene Interaction database (DGIdb) mines existing resources that generate hypotheses about how mutated genes might be targeted therapeutically or prioritized for drug development. It provides an interface for searching lists of genes against a compendium of drug-gene interactions and potentially 'druggable' genes. DGIdb can be accessed at http://dgidb.org/ .

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Publisher

Nature Publishing Group US,Nature Publishing Group

Subject

631/114/129

/ 631/114/2164

/ 631/114/2401

/ 631/154

/ Antineoplastic Agents - chemistry

/ Bioinformatics

/ Biological Microscopy