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Airspace Dimension Assessment (AiDA) by inhaled nanoparticles: benchmarking with hyperpolarised 129Xe diffusion-weighted lung MRI
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Airspace Dimension Assessment (AiDA) by inhaled nanoparticles: benchmarking with hyperpolarised 129Xe diffusion-weighted lung MRI
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Journal Article
Airspace Dimension Assessment (AiDA) by inhaled nanoparticles: benchmarking with hyperpolarised 129Xe diffusion-weighted lung MRI
2021
Overview
Enlargements of distal airspaces can indicate pathological changes in the lung, but accessible and precise techniques able to measure these regions are lacking. Airspace Dimension Assessment with inhaled nanoparticles (AiDA) is a new method developed for in vivo measurement of distal airspace dimensions. The aim of this study was to benchmark the AiDA method against quantitative measurements of distal airspaces from hyperpolarised
129
Xe diffusion-weighted (DW)-lung magnetic resonance imaging (MRI). AiDA and
129
Xe DW-MRI measurements were performed in 23 healthy volunteers who spanned an age range of 23–70 years. The relationship between the
129
Xe DW-MRI and AiDA metrics was tested using Spearman’s rank correlation coefficient. Significant correlations were observed between AiDA distal airspace radius (
r
AiDA
) and mean
129
Xe apparent diffusion coefficient (ADC) (p < 0.005), distributed diffusivity coefficient (
DDC
) (p < 0.001) and distal airspace dimension (
Lm
D
) (p < 0.001). A mean bias of − 1.2 µm towards
r
AiDA
was observed between
129
Xe
Lm
D
and
r
AiDA
, indicating that
r
AiDA
is a measure of distal airspace dimension. The AiDA
R
0
intercept correlated with MRI
129
Xe α (p = 0.02), a marker of distal airspace heterogeneity. This study demonstrates that AiDA has potential to characterize the distal airspace microstructures and may serve as an alternative method for clinical examination of the lungs.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
