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The Cells and Circuitry for Itch Responses in Mice
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The Cells and Circuitry for Itch Responses in Mice
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Journal Article
The Cells and Circuitry for Itch Responses in Mice
2013
Overview
Itch is triggered by somatosensory neurons expressing the ion channel TRPV1 (transient receptor potential cation channel subfamily V member 1), but the mechanisms underlying this nociceptive response remain poorly understood. Here, we show that the neuropeptide natriuretic polypeptide b (Nppb) is expressed in a subset of TRPV1 neurons and found that Nppb -/- mice selectively lose almost all behavioral responses to itch-inducing agents. Nppb triggered potent scratching when injected intrathecally in wild-type and Nppb -/- mice, showing that this neuropeptide evokes itch when released from somatosensory neurons. Itch responses were blocked by toxin-mediated ablation of Nppb-receptor-expressing cells, but a second neuropeptide, gastrin-releasing peptide, still induced strong responses in the toxin-treated animals. Thus, our results define the primary pruriceptive neurons, characterize Nppb as an itch-selective neuropeptide, and reveal the next two stages of this dedicated neuronal pathway.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Fibers
/ Gastrin-Releasing Peptide - metabolism
/ Gastrin-Releasing Peptide - pharmacology
/ Glass fiber reinforced plastics
/ Horns
/ Male
/ Mice
/ Natriuretic Peptide, Brain - genetics
/ Natriuretic Peptide, Brain - metabolism
/ Natriuretic Peptide, Brain - pharmacology
/ Neurons
/ Peptides
/ Pruritus - chemically induced
/ Receptors, Atrial Natriuretic Factor - metabolism
/ Rodents
/ Sensory Receptor Cells - drug effects
/ Sensory Receptor Cells - metabolism
/ Signals
/ Spinal Cord - physiopathology
/ Switches
/ Toxins
