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Combined effect of microbially derived cecal SCFA and host genetics on feed efficiency in broiler chickens
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Combined effect of microbially derived cecal SCFA and host genetics on feed efficiency in broiler chickens
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Journal Article
Combined effect of microbially derived cecal SCFA and host genetics on feed efficiency in broiler chickens
2023
Overview
Background
Improving feed efficiency is the most important goal for modern animal production. The regulatory mechanisms of controlling feed efficiency traits are extremely complex and include the functions related to host genetics and gut microbiota. Short-chain fatty acids (SCFAs), as significant metabolites of microbiota, could be used to refine the combined effect of host genetics and gut microbiota. However, the association of SCFAs with the gut microbiota and host genetics for regulating feed efficiency is far from understood.
Results
In this study, 464 broilers were housed for RFI measuring and examining the host genome sequence. And 300 broilers were examined for cecal microbial data and SCFA concentration. Genome-wide association studies (GWAS) showed that four out of seven SCFAs had significant associations with genome variants. One locus (chr4: 29414391–29417189), located near or inside the genes
MAML3
,
SETD7
, and
MGST2
, was significantly associated with propionate and had a modest effect on feed efficiency traits and the microbiota. The genetic effect of the top SNP explained 8.43% variance of propionate. Individuals with genotype AA had significantly different propionate concentrations (0.074 vs. 0.131 μg/mg), feed efficiency (FCR: 1.658 vs. 1.685), and relative abundance of 14 taxa compared to those with the GG genotype.
Christensenellaceae
and
Christensenellaceae_R-7_group
were associated with feed efficiency, propionate concentration, the top SNP genotypes, and lipid metabolism. Individuals with a higher cecal abundance of these taxa showed better feed efficiency and lower concentrations of caecal SCFAs.
Conclusion
Our study provides strong evidence of the pathway that host genome variants affect the cecal SCFA by influencing caecal microbiota and then regulating feed efficiency. The cecal taxa
Christensenellaceae
and
Christensenellaceae_R-7_group
were identified as representative taxa contributing to the combined effect of host genetics and SCFAs on chicken feed efficiency. These findings provided strong evidence of the combined effect of host genetics and gut microbial SCFAs in regulating feed efficiency traits.
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Video Abstract
Publisher
BioMed Central,Springer Nature B.V,BMC
Subject
/ Appetite
/ Biomedical and Life Sciences
/ Birds
/ Broiler
/ Cecum
/ Chickens
/ Feeds
/ Gastrointestinal Microbiome - genetics
/ Genome-wide association studies
/ Genome-Wide Association Study
/ Genomes
/ Genotype
/ Gut Microbiome and Animal Health
/ Microbial Genetics and Genomics
/ Poultry
/ SCFAs
/ Single-nucleotide polymorphism
/ Virology
