Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer

by van Galen, Peter , Mullighan, Charles G. , Dick, John E. , Notta, Faiyaz , Pollett, Aaron , Brown, Andrew M. K. , Shibata, Darryl , McPherson, John , Dunant, Cyrille , Wienholds, Erno , Ma, Jing , Kreso, Antonija , O'Brien, Catherine A. , Gan, Olga I. , Ng, Karen , Gallinger, Steven

in Animals / Cancer / Cell growth / Cell Lineage / Cell Tracking / Cells / Cellular biology / Chemotherapy / Clonal Evolution - genetics / Clone Cells / Cloning / Colorectal cancer / Colorectal carcinoma / colorectal neoplasms / Colorectal Neoplasms - drug therapy / Colorectal Neoplasms - genetics / Colorectal Neoplasms - pathology / DNA Copy Number Variations / Drug Resistance, Neoplasm - genetics / drug therapy / drugs / Dynamics / epigenetics / Genetic diversity / Genetics / Heterogeneity / Heterologous transplantation / Human behavior / Humans / Lentivirus / Mice / mutation / neoplasm cells / Neoplasm Transplantation / Proportions / Repopulation / Survival / Transcriptome / Transduction, Genetic / Transplantation / Tumor Cells, Cultured / Tumors

2013

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer

2013

Confirm

Do you wish to request the book?

Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer

2013

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer

van Galen, Peter,

Mullighan, Charles G.,

Dick, John E.,

Notta, Faiyaz,

Pollett, Aaron,

Brown, Andrew M. K.,

Shibata, Darryl,

McPherson, John,

Dunant, Cyrille,

Wienholds, Erno,

Ma, Jing,

Kreso, Antonija,

O'Brien, Catherine A.,

Gan, Olga I.,

Ng, Karen,

Gallinger, Steven

2013

Overview

Intratumoral heterogeneity arises through the evolution of genetically diverse subclones during tumor progression. However, it remains unknown whether cells within single genetic clones are functionally equivalent. By combining DNA copy number alteration (CNA) profiling, sequencing, and lentiviral lineage tracking, we followed the repopulation dynamics of 150 single lentivirus-marked lineages from 10 human colorectal cancers through serial xenograft passages in mice. CNA and mutational analysis distinguished individual clones and showed that clones remained stable upon serial transplantation. Despite this stability, the proliferation, persistence, and chemotherapy tolerance of lentivirally marked lineages were variable within each clone. Chemotherapy promoted the dominance of previously minor or dormant lineages. Thus, apart from genetic diversity, tumor cells display inherent functional variability in tumor propagation potential, which contributes to both cancer growth and therapy tolerance.

Share this book

Add to My Shelf

Publisher

American Association for the Advancement of Science,The American Association for the Advancement of Science

Subject

/ Cancer

/ Cells