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PPARγ alleviates preeclampsia development by regulating lipid metabolism and ferroptosis
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PPARγ alleviates preeclampsia development by regulating lipid metabolism and ferroptosis
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Journal Article
PPARγ alleviates preeclampsia development by regulating lipid metabolism and ferroptosis
2024
Overview
The study aims to explore the effect of PPARγ signaling on ferroptosis and preeclampsia (PE) development. Serum and placental tissue are collected from healthy subjects and PE patients. The PPARγ and Nrf2 decreases in the PE. Rosiglitazone intervention reverses hypoxia-induced trophoblast ferroptosis and decreases lipid synthesis by regulating Nfr2 and SREBP1. Compared to the Hypoxia group, the migratory and invasive abilities enhance after rosiglitazone and ferr1 treatment. Rosiglitazone reduces the effect of hypoxia and erastin. The si-Nrf2 treatment attenuats the effects of rosiglitazone on proliferation, migration, and invasion. The si-Nrf2 does not affect SREBP1 expression. PPARγ agonists alleviates ferroptosis in the placenta of the PE rats. The study confirms that PPARγ signaling and ferroptosis-related indicators were dysregulated in PE. PPARγ/Nrf2 signaling affects ferroptosis by regulating lipid oxidation rather than SREBP1-mediated lipid synthesis. In conclusion, our study find that PPARγ can alleviate PE development by regulating lipid oxidation and ferroptosis.
Hypertension, and organ system dysfunctions associated with preeclampsia (PE) result in poor pregnancy outcomes. In the current study, the authors examined molecular pathogenesis of PE with a focus Peroxisome proliferator-activated receptor gamma (PPARγ), lipid metabolism, and ferroptosis in the placenta of PE patients.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
