Journal Article

Clinical evidence for acupuncture for adult asthma: Systematic review and meta-analysis of randomised sham/placebo-controlled trials

Liu, Shaonan, Xue, Charlie Changli, Lin, Lin, Zhang, Anthony Lin, Shergis, Johannah Linda, Guo, Xinfeng, Zheng, Lici, Pang, Jintao, Wu, Lei

2023

Overview

Acupuncture is a widely used asthma therapy, but the benefits remain uncertain. This study aimed to access the effectiveness of acupuncture for treatment of asthma in adults. Five English databases and four Chinese databases were searched from inception to November 2021. Randomised sham/placebo-controlled trials meeting inclusion criteria were included. Risk of bias was evaluated according to the Cochrane Review Handbook, and data analysis was performed in RevMan 5.4.1. Quality of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluations (GRADE) profiler. Sixteen randomised controlled trials (RCTs) were included in the meta-analysis. Results indicated that acupuncture was well-tolerated and could improve FEV1% compared with sham/placebo acupuncture [MD 6.11, 95% CI 0.54–11.68, I2 = 93%, number of participants (n) = 603]. Acupuncture also improved Cai’s Asthma Quality of Life Questionnaire (AQLQ) (MD 7.26, 95% CI 5.02–9.50, I2 = 0, n = 358), and reduced the asthma symptom score (SMD −2.73, 95% CI −3.59 to −1.87, I2 = 65%, n = 120). One study showed acupuncture increased the Asthma Control Test (ACT) score (MD 2.00, 95% CI 0.90–3.10, n = 111), and decreased exacerbation frequency (MD −1.00, 95% CI −1.55 to −1.45, n = 111). Other lung function and medication use parameters were not statistically significant. Acupuncture versus sham/placebo control appeared to improve quality of life, FEV1%, symptoms, and asthma control, and reduced exacerbation frequency per year. Further studies with appropriate controls, more participants, and high-quality evidence are needed. •This is the first systematic review focused on acupuncture for adults with asthma compared with sham/placebo acupuncture.•Acupuncture appeared to have improved asthma symptoms, asthma control and exacerbation.•Moderate-quality evidence showed that acupuncture could increase FEV1% and quality of life in adults asthma.

• Publisher: Elsevier Ltd,Elsevier Limited,Elsevier
• Subject: Acupuncture / Adult Asthma / Adults / Asthma / Bias / Clinical trials / Data analysis / Evidence / Intervention / Medical research / Meta-Analysis / Placebo / Placebos / Quality of life / Respiratory function / Sham / Statistical analysis / Systematic review / Traditional Chinese medicine