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Review of the biologic and clinical significance of genetic mutations in angioimmunoblastic T‐cell lymphoma
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Review of the biologic and clinical significance of genetic mutations in angioimmunoblastic T‐cell lymphoma
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Journal Article
Review of the biologic and clinical significance of genetic mutations in angioimmunoblastic T‐cell lymphoma
2018
Overview
Angioimmunoblastic T‐cell lymphoma (AITL) is an age‐related malignant lymphoma, characterized by immune system‐dysregulated symptoms. Recent sequencing studies have clarified the recurrent mutations in ras homology family member A (RHOA) and in genes encoding epigenetic regulators, tet methyl cytosine dioxygenase 2 (TET2), DNA methyl transferase 3 alpha (DNMT3A) and isocitrate dehydrogenase 2, mitochondrial (IDH2), as well as those related to the T‐cell receptor signaling pathway in AITL. In this review, we focus on how this genetic information has changed the understanding of the developmental process of AITL and will in future lead to individualized therapies for AITL patients. Recent progress in next‐generation sequencing has revealed the AITL specific genomic abnormalities in epigenetic regulators and TCR signaling. In this paper, we focused on the insights on how the biological and clinical aspects are linked to the genomic features of AITL.
Publisher
John Wiley & Sons, Inc,John Wiley and Sons Inc
Subject
/ angioimmunoblastic T‐cell lymphoma
/ Cytosine
/ DNA (Cytosine-5-)-Methyltransferases - genetics
/ DNA-Binding Proteins - genetics
/ Genes
/ Genetic Predisposition to Disease
/ Homology
/ Humans
/ Immunoblastic Lymphadenopathy - genetics
/ Isocitrate Dehydrogenase - genetics
/ Kinases
/ Lymphoma
/ multistep and multilineage tumorigenesis
/ Mutation
/ Proteins
/ Proto-Oncogene Proteins - genetics
/ ras homology family member A
/ Receptors, Antigen, T-Cell - genetics
/ Review
/ rhoA GTP-Binding Protein - genetics
