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A longitudinal pilot study in pre-menopausal women links cervicovaginal microbiome to CIN3 progression and recovery
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A longitudinal pilot study in pre-menopausal women links cervicovaginal microbiome to CIN3 progression and recovery
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Journal Article
A longitudinal pilot study in pre-menopausal women links cervicovaginal microbiome to CIN3 progression and recovery
2025
Overview
Increasing evidence suggests vaginal dysbiosis is associated with persistent high-risk human papillomavirus (hrHPV) infection and cervical intraepithelial neoplasia (CIN) development. In this pilot longitudinal study, we investigate the potential of vaginal microbiome biomarkers to predict CIN3 development in hrHPV-positive (hrHPV+) women of reproductive age and assess loop electrosurgical excision procedure (LEEP) outcomes.
Fifty-nine non-menopausal women 20–53 years old, with normal cytology, were selected from the ARTISTIC trial and followed up twice over six years. Vaginal microbiome was analysed by 16S rRNA sequencing. HrHPV+ women with CIN3 showed a significant overrepresentation of
Sneathia amnii
,
Megasphaera genomosp., Peptostreptococcus anaerobius and Achromobacter spanius
(
p
< 0.05). Successfully LEEP-treated hrHPV-negative women exhibited increased
Lactobacillus
species, especially
Lactobacillus gasseri
. Additionally,
Lactobacillus helveticus
,
suntoryeus
and
vaginalis
showed a potential protective role against CIN3 development.
These unique microbial biomarkers associated with CIN3 development and recovery following LEEP treatment bring new insights into the vaginal microbiome’s role on disease progression.
Examination of vaginal microbiome’s role in predicting CIN3 in high-risk HPV positive women.
Sneathia amnii
links to CIN3 incidence, while
Lactobacillus
, especially
L. gasseri
, is associated with successful treatment and potential protection.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 45/23
/ Adult
/ Biomedical and Life Sciences
/ Cervix
/ Cytology
/ Female
/ Humans
/ Papillomavirus Infections - microbiology
/ RNA, Ribosomal, 16S - genetics
/ rRNA 16S
/ Uterine Cervical Dysplasia - microbiology
/ Uterine Cervical Dysplasia - pathology
/ Uterine Cervical Dysplasia - surgery
/ Uterine Cervical Neoplasms - microbiology
/ Uterine Cervical Neoplasms - pathology
/ Uterine Cervical Neoplasms - surgery
/ Vagina
