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Gut microbiota profile in children affected by atopic dermatitis and evaluation of intestinal persistence of a probiotic mixture
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Gut microbiota profile in children affected by atopic dermatitis and evaluation of intestinal persistence of a probiotic mixture
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Journal Article
Gut microbiota profile in children affected by atopic dermatitis and evaluation of intestinal persistence of a probiotic mixture
2019
Overview
Atopic dermatitis (AD) has been hypothesised to be associated with gut microbiota (GM) composition. We performed a comparative study of the GM profile of 19 AD children and 18 healthy individuals aimed at identifying bacterial biomarkers associated with the disease. The effect of probiotic intake (
Bifidobacterium breve
plus
Lactobacillus salivarius
) on the modulation of GM and the probiotic persistence in the GM were also evaluated. Faecal samples were analysed by real-time PCR and 16S rRNA targeted metagenomics. Although the probiotics, chosen for this study, did not shape the entire GM profile, we observed the ability of these species to pass through the gastrointestinal tract and to persist (only
B. breve
) in the GM. Moreover, the GM of patients compared to CTRLs showed a dysbiotic status characterised by an increase of
Faecalibacterium, Oscillospira, Bacteroides, Parabacteroides
and
Sutterella
and a reduction of short-chain fatty acid (SCFA)-producing bacteria (i.e.,
Bifidobacterium, Blautia, Coprococcus, Eubacterium
and
Propionibacterium
). Taken togheter these results show an alteration in AD microbiota composition with the depletion or absence of some species, opening the way to future probiotic intervention studies.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 45/23
/ 45/77
/ 692/53
/ Child
/ Children
/ Dermatitis, Atopic - genetics
/ Dermatitis, Atopic - microbiology
/ Dermatitis, Atopic - pathology
/ Eczema
/ Female
/ Gastrointestinal Microbiome - genetics
/ Humanities and Social Sciences
/ Humans
/ Infant
/ Male
/ RNA, Ribosomal, 16S - genetics
/ rRNA 16S
/ Science
