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GATA4/6 regulate DHH transcription in rat adrenocortical autografts
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GATA4/6 regulate DHH transcription in rat adrenocortical autografts
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Journal Article
GATA4/6 regulate DHH transcription in rat adrenocortical autografts
2020
Overview
Adrenal cortex autotransplantation with ACTH stimulation may be an alternative therapy for patients with bilateral adrenalectomy to avoid adrenal crisis, but its underlying mechanism has not been elucidated. Previously, we detected
Dhh
upregulation in rat adrenocortical autografts after transplantation. Here, we investigated potential regulators such as
Gata4
,
Gata6
,
Sry
and
Sox9
which affect
Dhh
transcription in adrenocortical autografts with or without ACTH stimulation. In ACTH-stimulated autografts,
Gata4
and
Gata6
were downregulated compared to control autografts. This response was linked to
rDhh
repression. A reporter assay using the upstream region of
rDhh
and a GATA binding motif revealed that
rDhh
promoters were significantly upregulated by co-transfection with
Gata4
or
Gata6
or both.
Sry
and
Sox9
expression in autografts with or without ACTH stimulation were verified by PCR and RNAscope analyses. The ovarian differentiation factors
Foxl2
and
Rspo1
were also upregulated in the autografts.
Gata4
and
Gata6
were found to be significant factors in the regulation of
rDhh
expression and could be associated with adrenocortical autograft maintenance. Gonadal primordia with bipotential testicular and ovarian functions may also be present in these autografts.
Publisher
Nature Publishing Group UK,Nature Publishing Group
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