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Characterization of the CCAAT-binding transcription factor complex in the plant pathogenic fungus Fusarium graminearum
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Characterization of the CCAAT-binding transcription factor complex in the plant pathogenic fungus Fusarium graminearum
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Characterization of the CCAAT-binding transcription factor complex in the plant pathogenic fungus Fusarium graminearum
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Journal Article
Characterization of the CCAAT-binding transcription factor complex in the plant pathogenic fungus Fusarium graminearum
2020
Overview
The CCAAT sequence is a ubiquitous
cis
-element of eukaryotic promoters, and genes containing CCAAT sequences have been shown to be activated by the CCAAT-binding transcription factor complex in several eukaryotic model organisms. In general, CCAAT-binding transcription factors form heterodimers or heterotrimeric complexes that bind to CCAAT sequences within the promoters of target genes and regulate various cellular processes. To date, except Hap complex, CCAAT-binding complex has been rarely reported in fungi. In this study, we characterized two CCAAT-binding transcription factors (Fct1 and Fct2) in the plant pathogenic fungus
Fusarium graminearum
. Previously,
FCT1
and
FCT2
were shown to be related to DNA damage response among eight CCAAT-binding transcription factors in
F. graminearum
. We demonstrate that the nuclear CCAAT-binding complex of
F. graminearum
has important functions in various fungal developmental processes, not just DNA damage response but virulence and mycotoxin production. Moreover, the results of biochemical and genetic analyses revealed that Fct1 and Fct2 may form a complex and play distinct roles among the eight CCAAT-binding transcription factors encoded by
F. graminearum
. To the best of our knowledge, the results of this study represent a substantial advancement in our understanding of the molecular mechanisms underlying the functions of CCAAT-binding factors in eukaryotes.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
