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Melanin-Concentrating Hormone: Unique Peptide Neuronal System in the Rat Brain and Pituitary Gland
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Melanin-Concentrating Hormone: Unique Peptide Neuronal System in the Rat Brain and Pituitary Gland
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Journal Article
Melanin-Concentrating Hormone: Unique Peptide Neuronal System in the Rat Brain and Pituitary Gland
1986
Overview
A unique neuronal system was detected in the rat central nervous system by immunohistochemistry and radioimmunoassay with antibodies to salmon melanin-concentrating hormone (MCH). MCH-like immunoreactive (MCH-LI) cell bodies were confined to the hypothalamus. MCH-LI fibers were found throughout the brain but were most prevalent in hypothalamus, mesencephalon, and pons-medulla regions. High concentrations of MCH-LI were measured in the hypothalamic medial forebrain bundle (MFB), posterior hypothalamic nucleus, and nucleus of the diagonal band. Reversed-phase high-performance liquid chromatography of MFB extracts from rat brain indicate that MCH-like peptide from the rat has a different retention time than that of the salmon MCH. An osmotic stimulus (2% NaCl as drinking water for 120 hr) caused a marked increase in MCH-LI concentrations in the lateral hypothalamus and neurointermediate lobe. The present studies establish the presence of MCH-like peptide in the rat brain. The MCH-LI neuronal system is well situated to coordinate complex functions such as regulation of water intake.
Publisher
National Academy of Sciences of the United States of America,National Acad Sciences
Subject
Aminoacids, peptides. Hormones. Neuropeptides
/ Analytical, structural and metabolic biochemistry
/ Animals
/ Biological and medical sciences
/ Brain
/ Fluorescent Antibody Technique
/ Fundamental and applied biological sciences. Psychology
/ Hormones
/ Neurons
/ Peptides, Cyclic - metabolism
/ Pituitary Gland - metabolism
/ Pituitary Hormones - immunology
/ Pituitary Hormones - metabolism
/ Proteins
/ Rats
/ Salmon
/ Sodium
