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Journal Article
Associations of obesity susceptibility loci with hypertension in Chinese children
2013
Overview
Context:
Recent genome-wide association studies have identified several single-nucleotide polymorphisms (SNPs) that are associated with body mass index (BMI)/obesity.
Objective:
As obesity is an independent risk factor for hypertension, the objective of the study was to investigate the associations of obesity susceptibility loci with blood pressure (BP)/hypertension in a population of Chinese children.
Design, setting and participants:
This was a genotype–phenotype association study. Participants included 3077 Chinese children, aged 6–18 years. Based on the Chinese age- and sex-specific BP standards, 619 hypertensive cases and 2458 controls with normal BP were identified.
Main outcome measures:
BP was measured by auscultation using a standard clinical sphygmomanometer.
Results:
Of the 11 SNPs, only
FTO
rs9939609 was significantly associated with systolic BP (SBP;
P
=0.034) and three SNPs were significantly associated with diastolic BP (DBP;
GNPDA2
rs10938397:
P
=0.026;
FAIM2
rs7138803:
P
=0.015;
NPC1
rs1805081:
P
=0.031) after adjustment for age, sex and hypertension status. In addition, three SNPs were significantly associated with hypertension risk after adjustment for age and sex (
FTO
rs9939609: odds ratio (OR)=1.35, 95% confidence interval (CI) 1.12–1.62,
P
=0.001;
MC4R
rs17782313: OR=1.22, 95% CI 1.06–1.42,
P
=0.007;
GNPDA2
rs10938397: OR=1.17, 95% CI 1.02–1.34,
P
=0.021). After additional adjustment for BMI, none remained significant. The genetic risk score (GRS), based on three significant SNPs (
FTO
rs9939609,
MC4R
rs17782313,
GNPDA2
rs10938397), showed a positive association with SBP (
P
=5.17 × 10
−4
) and risk of hypertension (OR=1.22, 95% CI 1.12–1.33,
P
=6.07 × 10
−6
). Further adjustment for BMI abolished the positive associations (SBP:
P
=0.220; DBP:
P
=0.305; hypertension:
P
=0.052). Only
FTO
rs9939609 and GRS were statistically associated with hypertension risk in the age- and sex-adjusted model after correction for multiple testing.
Conclusions:
The present study demonstrated that
FTO
rs9939609 and combined SNPs were significantly associated with risk of hypertension, which seems to be dependent on BMI.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Age
/ Alpha-Ketoglutarate-Dependent Dioxygenase FTO
/ Arterial hypertension. Arterial hypotension
/ Asian Continental Ancestry Group - genetics
/ Biological and medical sciences
/ Brain-Derived Neurotrophic Factor - genetics
/ Child
/ Complications and side effects
/ Diabetes
/ Female
/ Genetic Predisposition to Disease
/ Genome-Wide Association Study
/ Genomes
/ Health Promotion and Disease Prevention
/ Humans
/ Male
/ Medicine
/ Obesity
/ Pediatric Obesity - epidemiology
/ Pediatric Obesity - genetics
/ Polymorphism, Single Nucleotide
