Asset Details
Do you wish to reserve the book?
Glycolytic fast‐twitch muscle fiber restoration counters adverse age‐related changes in body composition and metabolism
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Glycolytic fast‐twitch muscle fiber restoration counters adverse age‐related changes in body composition and metabolism
Do you wish to request the book?
Glycolytic fast‐twitch muscle fiber restoration counters adverse age‐related changes in body composition and metabolism
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Glycolytic fast‐twitch muscle fiber restoration counters adverse age‐related changes in body composition and metabolism
2014
Overview
Summary Aging is associated with the development of insulin resistance, increased adiposity, and accumulation of ectopic lipid deposits in tissues and organs. Starting in mid‐life there is a progressive decline in lean muscle mass associated with the preferential loss of glycolytic, fast‐twitch myofibers. However, it is not known to what extent muscle loss and metabolic dysfunction are causally related or whether they are independent epiphenomena of the aging process. Here, we utilized a skeletal‐muscle‐specific, conditional transgenic mouse expressing a constitutively active form of Akt1 to examine the consequences of glycolytic, fast‐twitch muscle growth in young vs. middle‐aged animals fed standard low‐fat chow diets. Activation of the Akt1 transgene led to selective skeletal muscle hypertrophy, reversing the loss of lean muscle mass observed upon aging. The Akt1‐mediated increase in muscle mass led to reductions in fat mass and hepatic steatosis in older animals, and corrected age‐associated impairments in glucose metabolism. These results indicate that the loss of lean muscle mass is a significant contributor to the development of age‐related metabolic dysfunction and that interventions that preserve or restore fast/glycolytic muscle may delay the onset of metabolic disease.
Publisher
John Wiley & Sons, Inc,BlackWell Publishing Ltd
Subject
/ Aging
/ Anabolic Agents - pharmacology
/ Animals
/ Body Composition - drug effects
/ diabetes
/ Enzyme Activation - drug effects
/ exercise
/ Gene Expression Regulation - drug effects
/ Intercellular Signaling Peptides and Proteins - pharmacology
/ Mice
/ mTOR
/ Muscle Development - drug effects
/ Muscle Development - genetics
/ Muscle Fibers, Fast-Twitch - drug effects
/ Muscle Fibers, Fast-Twitch - enzymology
/ Muscle Fibers, Fast-Twitch - metabolism
/ Muscle Fibers, Fast-Twitch - pathology
/ Muscles
/ Original
