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Alogliptin improves survival and health of mice on a high‐fat diet
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Alogliptin improves survival and health of mice on a high‐fat diet
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Journal Article
Alogliptin improves survival and health of mice on a high‐fat diet
2019
Overview
Alogliptin is a commonly prescribed drug treating patients with type 2 diabetes. Here, we show that long‐term intervention with alogliptin (0.03% w/w in diet) improves survival and health of mice on a high‐fat diet. Alogliptin intervention takes beneficial effects associated with longevity, including increased insulin sensitivity, attenuated functionality decline, decreased organ pathology, preserved mitochondrial function, and reduced oxidative stress. Autophagy activation is proposed as an underlying mechanism of these beneficial effects. We conclude that alogliptin intervention could be considered as a potential strategy for extending lifespan and healthspan in obesity and overweight.
Publisher
John Wiley & Sons, Inc,John Wiley and Sons Inc
Subject
/ Aging
/ Animals
/ Diabetes
/ Diabetes mellitus (non-insulin dependent)
/ Diet, High-Fat - adverse effects
/ Drugs
/ GLP‐1
/ Health
/ Insulin
/ Male
/ Mice
/ Mitochondria, Liver - drug effects
/ Mitochondria, Liver - metabolism
/ Mitochondria, Liver - pathology
/ Obesity
/ Original
/ Studies
/ Survival
