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Epigallocatechin Gallate-Modified Silver Nanoparticles Show Antiviral Activity against Herpes Simplex Type 1 and 2

by Obuch-Woszczatyńska, Oliwia , Krzyzowska, Malgorzata , Patrycy, Magdalena , Celichowski, Grzegorz , Tomaszewska, Emilia , Janicka, Martyna , Chodkowski, Marcin , Ranoszek-Soliwoda, Katarzyna , Grobelny, Jaroslaw

in Acids / adjuvants / Animal models / Antiviral activity / Antiviral drugs / antiviral properties / Aqueous solutions / Care and treatment / Catechin / CD8 antigen / CXCL10 protein / Cytotoxicity / Dendritic cells / Dengue fever / disinfectants / DNA / DNA viruses / Epigallocatechin gallate / Flavonoids / Glycoproteins / Health aspects / Heparan sulfate / Hepatitis C / Herpes simplex / Herpes viruses / HSV-1 / HSV-2 / Human alphaherpesvirus 1 / Human papillomavirus / humans / Infections / Infiltration / Keratinocytes / Lymphocytes T / mice / Microbicides / Monocytes / Mucosa / Nanoparticles / nanosilver / Nitrates / Penicillin / RNA / RNA viruses / Seeds / Silver / Sodium / Sodium chloride / viruses / West Nile virus / α-Interferon / γ-Interferon

2023

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Epigallocatechin Gallate-Modified Silver Nanoparticles Show Antiviral Activity against Herpes Simplex Type 1 and 2

2023

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Epigallocatechin Gallate-Modified Silver Nanoparticles Show Antiviral Activity against Herpes Simplex Type 1 and 2

2023

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Journal Article

Epigallocatechin Gallate-Modified Silver Nanoparticles Show Antiviral Activity against Herpes Simplex Type 1 and 2

Obuch-Woszczatyńska, Oliwia,

Krzyzowska, Malgorzata,

Patrycy, Magdalena,

Celichowski, Grzegorz,

Tomaszewska, Emilia,

Janicka, Martyna,

Chodkowski, Marcin,

Ranoszek-Soliwoda, Katarzyna,

Grobelny, Jaroslaw

2023

Overview

(1) Background: Epigallocatechin gallate (EGCG) has been recognized as a flavonoid showing antiviral activity against various types of DNA and RNA viruses. In this work, we tested if EGCG-modified silver nanoparticles (EGCG-AgNPs) can become novel microbicides with additional adjuvant properties to treat herpes infections. (2) Methods: The anti-HSV and cytotoxic activities of EGCG-AgNPs were tested in human HaCaT and VK-2-E6/E7 keratinocytes. HSV-1/2 titers and immune responses after treatment with EGCG-AgNPs were tested in murine models of intranasal HSV-1 infection and genital HSV-2 infection. (3) Results: EGCG-AgNPs inhibited attachment and entry of HSV-1 and HSV-2 in human HaCaT and VK-2-E6/E7 keratinocytes much better than EGCG at the same concentration. Infected mice treated intranasally (HSV-1) or intravaginally (HSV-2) with EGCG-AgNPs showed lower virus titers in comparison to treatment with EGCG alone. After EGCG-AgNPs treatment, mucosal tissues showed a significant infiltration in dendritic cells and monocytes in comparison to NaCl-treated group, followed by significantly better infiltration of CD8+ T cells, NK cells and increased expression of IFN-α, IFN-γ, CXCL9 and CXCL10. (4) Conclusions: Our findings show that EGCG-AgNPs can become an effective novel antiviral microbicide with adjuvant properties to be applied upon the mucosal tissues.

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MDPI AG,MDPI

Subject

/ antiviral properties

/ Aqueous solutions