Asset Details
Do you wish to reserve the book?
Prophages mediate defense against phage infection through diverse mechanisms
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Prophages mediate defense against phage infection through diverse mechanisms
Do you wish to request the book?
Prophages mediate defense against phage infection through diverse mechanisms
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Prophages mediate defense against phage infection through diverse mechanisms
2016
Overview
The activity of bacteriophages poses a major threat to bacterial survival. Upon infection, a temperate phage can either kill the host cell or be maintained as a prophage. In this state, the bacteria carrying the prophage is at risk of superinfection, where another phage injects its genetic material and competes for host cell resources. To avoid this, many phages have evolved mechanisms that alter the bacteria and make it resistant to phage superinfection. The mechanisms underlying these phentoypic conversions and the fitness consequences for the host are poorly understood, and systematic studies of superinfection exclusion mechanisms are lacking. In this study, we examined a wide range of
Pseudomonas aeruginosa
phages and found that they mediate superinfection exclusion through a variety of mechanisms, some of which affected the type IV pilus and O-antigen, and others that functioned inside the cell. The strongest resistance mechanism was a surface modification that we showed is cost-free for the bacterial host in a natural soil environment and in a
Caenorhabditis. elegans
infection model. This study represents the first systematic approach to address how a population of prophages influences phage resistance and bacterial behavior in
P. aeruginosa
.
Publisher
Nature Publishing Group UK,Oxford University Press,Nature Publishing Group
Subject
/ Bacteria
/ Bacterial Proteins - genetics
/ Bacterial Proteins - metabolism
/ Biomedical and Life Sciences
/ Ecology
/ Fimbriae, Bacterial - genetics
/ Fimbriae, Bacterial - metabolism
/ Microbial Genetics and Genomics
/ Original
/ Phages
/ Pseudomonas aeruginosa - genetics
/ Pseudomonas aeruginosa - metabolism
