Asset Details
Do you wish to reserve the book?
Peptide-Based Regulation of TNF-α-Mediated Cytotoxicity
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Peptide-Based Regulation of TNF-α-Mediated Cytotoxicity
Do you wish to request the book?
Peptide-Based Regulation of TNF-α-Mediated Cytotoxicity
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Peptide-Based Regulation of TNF-α-Mediated Cytotoxicity
2025
Overview
Tumor necrosis factor alpha (TNF-α) is a pro-inflammatory cytokine associated with TNF receptor 1 (TNFR1) and TNF receptor 2 (TNFR2), which play important roles in several inflammatory diseases. There is a growing interest in developing alternative molecules that can be used as TNF blockers. In this study, we focused on TNF-α-, TNFR1-, and TNFR2-mimicking peptides to inhibit TNF-α receptor binding in various ways. Six peptides (OB1, OB2, OB5, OB6, OB7, and OB8) were developed to bind TNFR1, TNFR2, and TNF-α. OB1 and OB2 bound to TNF-α with lower Kd values of 300 and 46.7 nM, respectively, compared to previously published sequences. These synthetic peptides directly and indirectly inhibited TNF-α in vitro without cytotoxicity to L929 cells, and OB1 significantly inhibited apoptosis in the presence of hTNF-α. Peptides developed in this study may prove to be useful for therapeutic inhibition of TNF-α.
Publisher
MDPI AG,MDPI
Subject
/ Animals
/ Enzymes
/ Humans
/ Kinases
/ Mice
/ Peptides
/ Proteins
/ Receptors, Tumor Necrosis Factor, Type I - antagonists & inhibitors
/ Receptors, Tumor Necrosis Factor, Type I - metabolism
/ Receptors, Tumor Necrosis Factor, Type II - antagonists & inhibitors
/ Receptors, Tumor Necrosis Factor, Type II - chemistry
/ Receptors, Tumor Necrosis Factor, Type II - metabolism
/ TNF-α
/ Tumor necrosis factor receptors
/ Tumor Necrosis Factor-alpha - metabolism
