Asset Details
Do you wish to reserve the book?
The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation
Do you wish to request the book?
The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation
2016
Overview
Cross-linkage of the high-affinity immunoglobulin E (IgE) receptor (FcɛRI) on mast cells by antigen ligation has a critical role in the pathology of IgE-dependent allergic disorders, such as anaphylaxis and asthma. Restraint of intracellular signal transduction pathways that promote release of mast cell-derived pro-inflammatory mediators is necessary to dampen activation and restore homoeostasis. Here we show that the ligase Nedd4-2 and the adaptor Ndfip1 (Nedd4 family interacting protein 1) limit the intensity and duration of IgE-FcɛRI-induced positive signal transduction by ubiquitinating phosphorylated Syk, a tyrosine kinase that is indispensable for downstream FcɛRI signalosome activity. Importantly, loss of Nedd4-2 or Ndfip1 in mast cells results in exacerbated and prolonged IgE-mediated cutaneous anaphylaxis
in vivo
. Our findings reveal an important negative regulatory function for Nedd4-2 and Ndfip1 in IgE-dependent mast cell activity.
Aberrant activation of the IgE receptor on mast cells leads to allergic responses. Here, the authors identify an E3 ligase and adaptor protein that can reduce IgE signalling by targeting phosphorylated-Syk for degradation.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/106
/ 13/21
/ 14
/ 64
/ 64/60
/ 82
/ 96/31
/ 96/95
/ Animals
/ Antigens
/ Asthma
/ Carrier Proteins - immunology
/ Carrier Proteins - metabolism
/ Cells
/ Female
/ Humanities and Social Sciences
/ Immunoglobulin E - immunology
/ Immunoglobulin E - metabolism
/ Kinases
/ Male
/ Mast Cells - transplantation
/ Membrane Proteins - genetics
/ Membrane Proteins - immunology
/ Membrane Proteins - metabolism
/ Nedd4 Ubiquitin Protein Ligases - genetics
/ Nedd4 Ubiquitin Protein Ligases - immunology
/ Nedd4 Ubiquitin Protein Ligases - metabolism
/ Passive Cutaneous Anaphylaxis - genetics
/ Passive Cutaneous Anaphylaxis - immunology
/ Proteins
/ Science
