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X-ray inactivation of RNA viruses without loss of biological characteristics
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Journal Article
X-ray inactivation of RNA viruses without loss of biological characteristics
2020
Overview
In the event of an unpredictable viral outbreak requiring high/maximum biosafety containment facilities (i.e. BSL3 and BSL4), X-ray irradiation has the potential to relieve pressures on conventional diagnostic bottlenecks and expediate work at lower containment. Guided by Monte Carlo modelling and in vitro 1-log
10
decimal-reduction value (D-value) predictions, the X-ray photon energies required for the effective inactivation of zoonotic viruses belonging to the medically important families of
Flaviviridae
,
Nairoviridae
,
Phenuiviridae
and
Togaviridae
are demonstrated. Specifically, it is shown that an optimized irradiation approach is attractive for use in a multitude of downstream detection and functional assays, as it preserves key biochemical and immunological properties. This study provides evidence that X-ray irradiation can support emergency preparedness, outbreak response and front-line diagnostics in a safe, reproducible and scalable manner pertinent to operations that are otherwise restricted to higher containment BSL3 or BSL4 laboratories.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 631/326
/ Animals
/ Energy
/ Humanities and Social Sciences
/ Humans
/ Nairovirus - radiation effects
/ RNA Viruses - radiation effects
/ RNA, Viral - radiation effects
/ Science
/ Togaviridae - radiation effects
/ Viral Zoonoses - prevention & control
/ Viruses
/ X-rays
/ Zika Virus - radiation effects
/ Zoonoses
