Journal Article

Several implications for the pathogenesis and treatment of thrombosis in PNH patients according to multiomics analysis

Chen, Yingying, Fu, Rong, Liu, Chunyan, Meng, Xiaorui, Wang, Yinxing

2024

Overview

Through Augur analysis, we found that myeloid cells, including neutrophils, myelocytes and monocytes, contributed significantly to the thrombotic phenotype (Fig. 1D). [...]we analyzed the DEGs of myeloid cells and found that genes related to leukocyte activation, adhesion and migration to the endothelium were upregulated, while genes related to leukocyte-mediated immunity and cell killing were downregulated (Fig. 1E, F). Enrichment analysis shows that the differentially expressed proteins (DEPs) are involved in cell adhesion, platelet activation, fibrinogen complex, and complement and coagulation cascade (Fig. 1H, Additional file 1: [...]we demonstrate that platelet activation, coagulation cascades, and leukocyte cell adhesion are closely related to thrombosis in PNH patients at multiple levels of gene, transcription, and protein.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Analysis / Anticoagulants / Anticoagulants (Medicine) / Biomedical and Life Sciences / Biomedicine / Blood clot / Blood clots / Blood platelets / Care and treatment / Cell activation / Cell adhesion / Cell adhesion & migration / Coagulation / Complement activation / Complications and side effects / Dosage and administration / Endothelium / Fibrinogen / Gene mutations / Genes / Genetic aspects / Health aspects / Hemoglobinuria, Paroxysmal / Letter to the Editor / Leukocyte migration / Leukocytes / Leukocytes (neutrophilic) / Medicine/Public Health / Monocytes / Mutation / Myelocytes / Myeloid cells / Phenotypes / Platelets / Prevention / Proteins / Proteomics / Pulmonary embolisms / Purpura / Risk factors / Thrombosis / Transcription activation / Translational hematology