Journal Article

Association between vitamin B2 intake and prostate-specific antigen in American men: 2003–2010 National Health and Nutrition Examination Survey

Li, Xin-yu, Lv, Jia-jie, Wang, Jing-bing, Li, Wen-zhi, Kong, Xiang-Meng, Cheng, Zhi-hua, Wang, Xu-hui, Zhang, Lin-jie, Zhao, Yan, Yang, Cheng-hao, Yang, Xi-tao

2024

Overview

Background Accumulating evidence suggests a pivotal role of vitamin B2 in the pathogenesis and progression of prostate cancer (PCa). Vitamin B2 intake has been postulated to modulate the screening rate for PCa by altering the concentration of prostate-specific antigen(PSA). However, the relationship between vitamin B2 and PSA remains indeterminate. Hence, we conducted a comprehensive evaluation of the association between vitamin B2 intake and PSA levels, utilizing data from the National Health and Nutrition Examination Survey (NHANES) database. Methods From a pool of 20,371 participants in the NHANES survey conducted between 2003 and 2010, a cohort of 2,323 participants was selected for the present study. The male participants were classified into four distinct groups based on their levels of vitamin B2 intake. We employed a multiple linear regression model and a non-parametric regression method to investigate the relationship between vitamin B2 and PSA levels. Results The study cohort comprised of 2,323 participants with a mean age of 54.95 years (± 11.73). Our findings revealed a statistically significant inverse correlation between vitamin B2 intake (mg) and PSA levels, with a reduction of 0.13 ng/ml PSA concentration for every unit increase in vitamin B2 intake. Furthermore, we employed a fully adjusted model to construct a smooth curve to explore the possible linear relationship between vitamin B2 intake and PSA concentration. Conclusions Our study in American men has unveiled a notable inverse association between vitamin B2 intake and PSA levels, potentially posing a challenge for the identification of asymptomatic prostate cancer. Specifically, our findings suggest that individuals with higher vitamin B2 intake may be at a greater risk of being diagnosed with advanced prostate cancer in the future, possibly indicating a detection bias. These results may offer a novel explanation for the observed positive correlation between vitamin B2 intake and prostate cancer.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Adult / Aged / Antigens / Biostatistics / Care and treatment / Confounding (Statistics) / Data analysis / Diagnosis / Dietary supplements / Disease control / Dosage and administration / Environmental Health / Epidemiology / Health surveys / Humans / Hypotheses / Immune system / Male / Medical screening / Medicine / Medicine & Public Health / Metabolism / Middle Aged / Missing data / National Health and Nutrition Examination Survey (NHANES) / Nutrition / Nutrition Surveys / Pathogenesis / Population / Prostate cancer / Prostate-specific antigen / Prostate-Specific Antigen - blood / Prostatic Neoplasms - blood / Prostatic Neoplasms - epidemiology / Public Health / Regression analysis / Regression models / Riboflavin / Riboflavin - administration & dosage / Risk factors / Statistical analysis / Surveys / Testing / United States - epidemiology / Vaccine / Variables / Vitamin B2 / Vitamins