Journal Article

Examination of the association between exposure to childhood maltreatment and brain structure in young adults: a machine learning analysis

Sylvane, Desrivières, Whelan, Robert, Artiges Eric, Potter, Alexandra, Hohmann, Sarah, Brier Zoe M F, Grigis Antoine, Nees Frauke, Martinot Jean-Luc, Heinz, Andreas, Allgaier, Nicholas, Hahn Sage, van Stolk-Cooke Katherine, Flor Herta, Papadopoulos, Orfanos Dimitri, Price, Matthew, Albaugh, Matthew, Smolka, Michael N, Fani Negar, Paillère Marie-Laure, Gowland, Penny, Juliano, Anthony C, Ittermann Bernd, Garavan Hugh, Poustka Luise, Peck, Kelly, Fröhner, Juliane H, Banaschewski Tobias, Walter, Henrik, Schumann Gunter, Legrand, Alison C, Bader, Chaarani, Quinlan, Erin Burke, Bokde Arun L W

2021

Overview

Exposure to maltreatment during childhood is associated with structural changes throughout the brain. However, the structural differences that are most strongly associated with maltreatment remain unclear given the limited number of whole-brain studies. The present study used machine learning to identify if and how brain structure distinguished young adults with and without a history of maltreatment. Young adults (ages 18–21, n = 384) completed an assessment of childhood trauma exposure and a structural MRI as part of the IMAGEN study. Elastic net regularized regression was used to identify the structural features that identified those with a history of maltreatment. A generalizable model that included 7 cortical thicknesses, 15 surface areas, and 5 subcortical volumes was identified (area under the receiver operating characteristic curve = 0.71, p < 0.001). Those with a maltreatment history had reduced surface areas and cortical thicknesses primarily in fronto-temporal regions. This group also had larger cortical thicknesses in occipital regions and surface areas in frontal regions. The results suggest childhood maltreatment is associated with multiple measures of structure throughout the brain. The use of a large sample without exposure to adulthood trauma provides further evidence for the unique contribution of childhood trauma to brain structure. The identified regions overlapped with regions associated with psychopathology in adults with maltreatment histories, which offers insights as to how these disorders manifest.

• Publisher: Nature Publishing Group
• Subject: Adolescent / Adult / Brain / Child / Child Abuse / Childhood / Children / Frontal Lobe / Humans / Learning algorithms / Life Sciences / Machine Learning / Magnetic Resonance Imaging / Prefrontal Cortex / Psychopathology / Sleep / Surface area / Trauma / Traumatic brain injury / Young Adult / Young adults