Asset Details
Do you wish to reserve the book?
Met induces diverse mammary carcinomas in mice and is associated with human basal breast cancer
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Met induces diverse mammary carcinomas in mice and is associated with human basal breast cancer
Do you wish to request the book?
Met induces diverse mammary carcinomas in mice and is associated with human basal breast cancer
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Met induces diverse mammary carcinomas in mice and is associated with human basal breast cancer
2009
Overview
Understanding the signaling pathways that drive aggressive breast cancers is critical to the development of effective therapeutics. The oncogene MET is associated with decreased survival in breast cancer, yet the role that MET plays in the various breast cancer subtypes is unclear. We describe a knockin mouse with mutationally activated Met (Metmut) that develops a high incidence of diverse mammary tumors with basal characteristics, including metaplasia, absence of progesterone receptor and ERBB2 expression, and expression of cytokeratin 5. With gene expression and tissue microarray analysis, we show that high MET expression in human breast cancers significantly correlated with estrogen receptor negative/ERBB2 negative tumors and with basal breast cancers. Few treatment options exist for breast cancers of the basal or trastuzumab-resistant ERBB2 subtypes. We conclude from these studies that MET may play a critical role in the development of the most aggressive breast cancers and may be a rational therapeutic target.
Publisher
National Academy of Sciences,National Acad Sciences
Subject
/ Animals
/ Breasts
/ Cancer
/ Female
/ Humans
/ Laboratory staining techniques
/ Mammary Neoplasms, Experimental - etiology
/ Mammary Neoplasms, Experimental - genetics
/ Mice
/ Proto-Oncogene Proteins c-met - genetics
/ Proto-Oncogene Proteins c-met - physiology
/ Receptors, Progesterone - analysis
/ Rodents
/ Tumors
