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Long-Term Colorectal-Cancer Incidence and Mortality after Lower Endoscopy
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Long-Term Colorectal-Cancer Incidence and Mortality after Lower Endoscopy
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Journal Article
Long-Term Colorectal-Cancer Incidence and Mortality after Lower Endoscopy
2013
Overview
Among 88,902 participants followed over a period of 22 years in the Nurses' Health Study and the Health Professionals Follow-up Study, colon cancer mortality was reduced after screening sigmoidoscopy (hazard ratio, 0.59) and screening colonoscopy (hazard ratio, 0.32).
Randomized, controlled trials have shown that screening with flexible sigmoidoscopy reduces the incidence of colorectal cancer and associated mortality, albeit with diminished effectiveness for cancers of the proximal colon.
1
–
3
Although comparable data from randomized, controlled trials of screening colonoscopy are not yet available,
4
colonoscopy is also widely endorsed by expert bodies for population-based screening, largely on the basis of case–control studies that show associations with reduced colorectal-cancer incidence and mortality.
5
–
9
However, as with flexible sigmoidoscopy, there is uncertainty about the effectiveness of colonoscopy in reducing the incidence of and mortality associated with proximal colon cancer
10
–
19
and about . . .
Publisher
Massachusetts Medical Society
Subject
/ Adenoma - prevention & control
/ Aged
/ Biological and medical sciences
/ Colorectal Neoplasms - diagnosis
/ Colorectal Neoplasms - epidemiology
/ Colorectal Neoplasms - mortality
/ Colorectal Neoplasms - prevention & control
/ Female
/ Gastroenterology. Liver. Pancreas. Abdomen
/ Humans
/ Male
/ Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
/ Mutation
/ Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
/ Tumors
