Journal Article

Prevalence and predictors of erectile dysfunction among men in the diabetes prevention program outcomes study

Blair, Yooni A., Pop-Busui, Rodica, Temprosa, Marinella, Doherty, Lindsay, Wessells, Hunter, Singh, Prachi, Gadde, Kishore M., Owora, Arthur H., Sarma, Aruna V.

2024

Overview

To determine burden and identify correlates of erectile dysfunction (ED) among men with prediabetes (PreD) and type 2 diabetes (T2D) enrolled in the Diabetes Prevention Program (DPP) Outcomes Study (DPPOS). The 2017 DPPOS visit included administration of the International Index of Erectile Function. Of 648 male participants, 88 % (n = 568) completed the survey. Associations between sociodemographic, behavioral, clinical, and glycemic measures at time of ED assessment, and ED were examined using multivariable logistic regression models in men with PreD and T2D separately. Overall, 218 (38 %) men met ED criteria. Prevalence was similar in men with PreD (41 %) and T2D (37 %) (p = 0.4). In all men, age (p < 0.001) increased odds of ED. Among men with PreD, those assigned to intensive lifestyle intervention (ILS), but not metformin, had decreased odds of ED compared with the placebo group (OR = 0.35, 95 % CI = 0.13, 0.94). Non-Hispanic White race was associated with increased odds of ED compared with other races (OR = 4.3; 95 % CI = 1.92, 9.65). Among men with T2D, ED risk did not differ by DPP treatment assignment; however, individuals with metabolic syndrome defined by National Cholesterol Education Program criteria, had increased odds of ED (OR = 1.85, 95 % CI = 1.14, 3.01), as did individuals with depression (OR = 2.05; 95 % CI = 1.10, 3.79). ED is prevalent in men with PreD and T2D. Our finding of reduced odds of ED in men randomized to ILS and with PreD suggests a potential opportunity for risk mitigation in the prediabetes interval. In men who have progressed to T2D, metabolic factors appear to be associated with ED. •Erectile dysfunction is prevalent in men with prediabetes and type 2 diabetes.•Reduced odds of ED in men with PreD randomized to ILS suggests an opportunity for risk mitigation in the prediabetes interval•In men who have progressed to T2D, metabolic factors appear to be associated with ED.

• Publisher: Elsevier Inc,Elsevier Limited
• Subject: Blood pressure / Clinical trials / Diabetes / Diabetes Mellitus, Type 2 - complications / Diabetes Mellitus, Type 2 - epidemiology / Diabetes Mellitus, Type 2 - prevention & control / Epidemiology / Erectile dysfunction / Erectile Dysfunction - complications / Erectile Dysfunction - epidemiology / Erectile Dysfunction - prevention & control / Exercise / Female / Glucose / Heart rate / Humans / Lifestyles / Male / Metabolic Syndrome - complications / Metabolism / Plasma / Prediabetes / Prediabetic State - complications / Prediabetic State - epidemiology / Prediabetic State - therapy / Prevalence / Prevention programs / Questionnaires / Risk Factors