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CD25890, a conserved protein that modulates sporulation initiation in Clostridioides difficile
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CD25890, a conserved protein that modulates sporulation initiation in Clostridioides difficile
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Journal Article
CD25890, a conserved protein that modulates sporulation initiation in Clostridioides difficile
2021
Overview
Bacteria that reside in the gastrointestinal tract of healthy humans are essential for our health, sustenance and well-being. About 50–60% of those bacteria have the ability to produce resilient spores that are important for the life cycle in the gut and for host-to-host transmission. A genomic signature for sporulation in the human intestine was recently described, which spans both commensals and pathogens such as
Clostridioides difficile
and contains several genes of unknown function. We report on the characterization of a signature gene,
CD25890
, which, as we show is involved in the control of sporulation initiation in
C. difficile
under certain nutritional conditions. Spo0A is the main regulatory protein controlling entry into sporulation and we show that an in-frame deletion of
CD25890
results in increased expression of
spo0A
per cell and increased sporulation. The effect of CD25890 on
spo0A
is likely indirect and mediated through repression of the
sinRR
´ operon. Deletion of the
CD25890
gene, however, does not alter the expression of the genes coding for the cytotoxins or the genes involved in biofilm formation. Our results suggest that CD25890 acts to modulate sporulation in response to the nutrients present in the environment.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
