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Single organelle analysis to characterize mitochondrial function and crosstalk during viral infection

by Zischka, Hans , Knolle, Percy , Aichler, Michaela , Manske, Katrin , Schneider, Annika , Kurz, Sandra , Misgeld, Thomas , Wohlleber, Dirk , Heikenwälder, Mathias , Janas, Marianne , Weissmann, Sebastian Felix

in 13/31 / 14/34 / 59/5 / 631/1647/1407/1492 / 631/250/255/2514 / 64/60 / Animals / Energy metabolism / Flow cytometry / HEK293 Cells / Hepatocytes - ultrastructure / Hepatocytes - virology / Humanities and Social Sciences / Humans / Infections / Membrane potential / Membrane Potential, Mitochondrial / Metabolism / Mice, Inbred C57BL / Mitochondria / Mitochondria, Liver - metabolism / Mitochondria, Liver - ultrastructure / Mitochondria, Liver - virology / multidisciplinary / Organelle Size / Phenotypes / Science / Science (multidisciplinary) / Viral infections / Virus Diseases - metabolism

2019

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Single organelle analysis to characterize mitochondrial function and crosstalk during viral infection

2019

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2019

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Journal Article

Single organelle analysis to characterize mitochondrial function and crosstalk during viral infection

Zischka, Hans,

Knolle, Percy,

Aichler, Michaela,

Manske, Katrin,

Schneider, Annika,

Kurz, Sandra,

Misgeld, Thomas,

Wohlleber, Dirk,

Heikenwälder, Mathias,

Janas, Marianne,

Weissmann, Sebastian Felix

2019

Overview

Mitochondria are key for cellular metabolism and signalling processes during viral infection. We report a methodology to analyse mitochondrial properties at the single-organelle level during viral infection using a recombinant adenovirus coding for a mitochondrial tracer protein for tagging and detection by multispectral flow cytometry. Resolution at the level of tagged individual mitochondria revealed changes in mitochondrial size, membrane potential and displayed a fragile phenotype during viral infection of cells. Thus, single-organelle and multi-parameter resolution allows to explore altered energy metabolism and antiviral defence by tagged mitochondria selectively in virus-infected cells and will be instrumental to identify viral immune escape and to develop and monitor novel mitochondrial-targeted therapies.

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Publisher

Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio

Subject

13/31

/ 14/34

/ 59/5

/ 631/1647/1407/1492

/ 631/250/255/2514

/ 64/60

/ Animals