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Microsecond time-resolved X-ray scattering by utilizing MHz repetition rate at second-generation XFELs

by Filipe, Diogo , Kirian, Richard A. , Lindsten, Fredrik , Kloos, Marco , Wollter, August , Bellisario, Alfredo , Koliyadu, Jayanath C. P. , Yenupuri, Tej Varma , Round, Adam , Mutisya, Jennifer , Maia, Filipe , Martin, Andrew V. , Westenhoff, Sebastian , Bean, Richard , Ducrocq, Gabriel , Nimmrich, Amke , You, Tong , Monrroy, Leonardo , Westphal, Daniel , Bielecki, Johan , Grubmueller, Helmut , Larkiala, Taru , Valerio, Joana , Letrun, Romain , Konold, Patrick E. , Koua, Faisal H. M. , Maihöfer, Michael , Sato, Tokushi , Adams, Patrick , Mészáros, Petra , Bódizs, Szabolcs , Okamoto, Kenta , Alvarez, Roberto

in 631/1647/2258 / 631/45/612 / 631/57/2272 / Bioinformatics / Biological Microscopy / Biological Techniques / Biomedical and Life Sciences / Biomedical Engineering/Biotechnology / Biomolecules / Brief Communication / Free electron lasers / Lasers / Life Sciences / Low noise / Molecular Biology / Molekylärbiologi / Noise levels / Protein folding / Proteins / Proteomics / Repetition / sample delivery / SAXS / Sensors / Time Factors / time-resolved studies / WAXS / X-Ray Diffraction - methods / X-ray scattering / X-Rays / XFELs

2024

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Microsecond time-resolved X-ray scattering by utilizing MHz repetition rate at second-generation XFELs

2024

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Microsecond time-resolved X-ray scattering by utilizing MHz repetition rate at second-generation XFELs

2024

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Journal Article

Microsecond time-resolved X-ray scattering by utilizing MHz repetition rate at second-generation XFELs

Filipe, Diogo,

Kirian, Richard A.,

Lindsten, Fredrik,

Kloos, Marco,

Wollter, August,

Bellisario, Alfredo,

Koliyadu, Jayanath C. P.,

Yenupuri, Tej Varma,

Round, Adam,

Mutisya, Jennifer,

Maia, Filipe,

Martin, Andrew V.,

Westenhoff, Sebastian,

Bean, Richard,

Ducrocq, Gabriel,

Nimmrich, Amke,

You, Tong,

Monrroy, Leonardo,

Westphal, Daniel,

Bielecki, Johan,

Grubmueller, Helmut,

Larkiala, Taru,

Valerio, Joana,

Letrun, Romain,

Konold, Patrick E.,

Koua, Faisal H. M.,

Maihöfer, Michael,

Sato, Tokushi,

Adams, Patrick,

Mészáros, Petra,

Bódizs, Szabolcs,

Okamoto, Kenta,

Alvarez, Roberto

2024

Overview

Detecting microsecond structural perturbations in biomolecules has wide relevance in biology, chemistry and medicine. Here we show how MHz repetition rates at X-ray free-electron lasers can be used to produce microsecond time-series of protein scattering with exceptionally low noise levels of 0.001%. We demonstrate the approach by examining Jɑ helix unfolding of a light-oxygen-voltage photosensory domain. This time-resolved acquisition strategy is easy to implement and widely applicable for direct observation of structural dynamics of many biochemical processes. The MHz repetition rates available at second-generation X-ray free-electron lasers enable the collection of microsecond time-resolved X-ray scattering data with exceptionally low noise, providing insights into protein structural dynamics.

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Publisher

Nature Publishing Group US,Nature Publishing Group

Subject

/ Biological Microscopy

/ Biological Techniques

/ Biomedical and Life Sciences