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Cell release during perfusion reflects cold ischemic injury in rat livers

by Markmann, James F. , Tessier, Shannon N. , van Gulik, Thomas M. , Uygun, Korkut , Hafiz, Ehab O. A. , Stott, Shannon L. , Yeh, Heidi , Pendexter, Casie A. , Marques, Beatriz , Cronin, Stephanie E. J. , de Vries, Reinier J. , Toner, Mehmet , Muzikansky, Alona

in 13/1 / 13/31 / 14/34 / 631/80/304 / 692/308/575 / 692/4020/4021/288 / 692/53/2423 / Animals / Biomarkers / Cell Separation - methods / Cold / Cold Temperature - adverse effects / Hepatic Stellate Cells - pathology / Hepatocytes / Hepatocytes - pathology / Humanities and Social Sciences / Hypothermia, Induced - adverse effects / Ischemia / Ischemia - etiology / Ischemia - pathology / Liver - blood supply / Liver - cytology / Liver - pathology / Liver Transplantation / multidisciplinary / Perfusion / Perfusion - adverse effects / Rats / Science / Science (multidisciplinary) / Transplantation

2020

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Cell release during perfusion reflects cold ischemic injury in rat livers

2020

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2020

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Journal Article

Cell release during perfusion reflects cold ischemic injury in rat livers

Markmann, James F.,

Tessier, Shannon N.,

van Gulik, Thomas M.,

Uygun, Korkut,

Hafiz, Ehab O. A.,

Stott, Shannon L.,

Yeh, Heidi,

Pendexter, Casie A.,

Marques, Beatriz,

Cronin, Stephanie E. J.,

de Vries, Reinier J.,

Toner, Mehmet,

Muzikansky, Alona

2020

Overview

The global shortage of donor organs has made it crucial to deeply understand and better predict donor liver viability. However, biomarkers that effectively assess viability of marginal grafts for organ transplantation are currently lacking. Here, we showed that hepatocytes, sinusoidal endothelial, stellate, and liver-specific immune cells were released into perfusates from Lewis rat livers as a result of cold ischemia and machine perfusion. Perfusate comparison analysis of fresh livers and cold ischemic livers showed that the released cell profiles were significantly altered by the duration of cold ischemia. Our findings show for the first time that parenchymal cells are released from organs under non-proliferative pathological conditions, correlating with the degree of ischemic injury. Thus, perfusate cell profiles could serve as potential biomarkers of graft viability and indicators of specific injury mechanisms during organ handling and transplantation. Further, parenchymal cell release may have applications in other pathological conditions beyond organ transplantation.

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Publisher

Nature Publishing Group UK,Nature Publishing Group

Subject

13/1

/ 13/31

/ 14/34