Asset Details
Do you wish to reserve the book?
Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species
Do you wish to request the book?
Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species
2021
Overview
Knowledge about in vivo effects of human circulating C-6 hydroxylated bile acids (BAs), also called muricholic acids, is sparse. It is unsettled if the gut microbiome might contribute to their biosynthesis. Here, we measured a range of serum BAs and related them to markers of human metabolic health and the gut microbiome. We examined 283 non-obese and obese Danish adults from the MetaHit study. Fasting concentrations of serum BAs were quantified using ultra-performance liquid chromatography-tandem mass-spectrometry. The gut microbiome was characterized with shotgun metagenomic sequencing and genome-scale metabolic modeling. We find that tauro- and glycohyocholic acid correlated inversely with body mass index (
P
= 4.1e-03,
P
= 1.9e-05, respectively), waist circumference (
P
= 0.017,
P
= 1.1e-04, respectively), body fat percentage (
P
= 2.5e-03,
P
= 2.3e-06, respectively), insulin resistance (
P
= 0.051,
P
= 4.6e-4, respectively), fasting concentrations of triglycerides (
P
= 0.06,
P
= 9.2e-4, respectively) and leptin (
P
= 0.067,
P
= 9.2e-4). Tauro- and glycohyocholic acids, and tauro-a-muricholic acid were directly linked with a distinct gut microbial community primarily composed of
Clostridia
species (
P
= 0.037,
P
= 0.013,
P
= 0.027, respectively). We conclude that serum conjugated C-6-hydroxylated BAs associate with measures of human metabolic health and gut communities of
Clostridia
species. The findings merit preclinical interventions and human feasibility studies to explore the therapeutic potential of these BAs in obesity and type 2 diabetes.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
