Asset Details
Do you wish to reserve the book?
Amorfrutins are potent antidiabetic dietary natural products
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Amorfrutins are potent antidiabetic dietary natural products
Do you wish to request the book?
Amorfrutins are potent antidiabetic dietary natural products
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Amorfrutins are potent antidiabetic dietary natural products
2012
Overview
Given worldwide increases in the incidence of obesity and type 2 diabetes, new strategies for preventing and treating metabolic diseases are needed. The nuclear receptor PPARγ (peroxisome proliferator-activated receptor gamma) plays a central role in lipid and glucose metabolism; however, current PPARγ-targeting drugs are characterized by undesirable side effects. Natural products from edible biomaterial provide a structurally diverse resource to alleviate complex disorders via tailored nutritional intervention. We identified a family of natural products, the amorfrutins, from edible parts of two legumes, Glycyrrhiza foetida and Amorpha fruticosa, as structurally new and powerful antidiabetics with unprecedented effects for a dietary molecule. Amorfrutins bind to and activate PPARγ, which results in selective gene expression and physiological profiles markedly different from activation by current synthetic PPARγ drugs. In diet-induced obese and db/db mice, amorfrutin treatment strongly improves insulin resistance and other metabolic and inflammatory parameters without concomitant increase of fat storage or other unwanted side effects such as hepatoxicity. These results show that selective PPARγ-activation by diet-derived ligands may constitute a promising approach to combat metabolic disease.
Publisher
National Academy of Sciences,National Acad Sciences
Subject
/ Agonists
/ Animals
/ Biological Products - chemistry
/ Biological Products - metabolism
/ Biological Products - pharmacology
/ Diabetes
/ Diabetes Mellitus, Type 2 - complications
/ Diabetes Mellitus, Type 2 - drug therapy
/ Diabetes Mellitus, Type 2 - etiology
/ Diet, High-Fat - adverse effects
/ drugs
/ etiology
/ Fabaceae
/ Gene Expression - drug effects
/ genetics
/ glucose
/ Humans
/ Hypoglycemic Agents - chemistry
/ Hypoglycemic Agents - metabolism
/ Hypoglycemic Agents - pharmacology
/ Insulin
/ Legumes
/ Ligands
/ Liver
/ Male
/ Mice
/ noninsulin-dependent diabetes mellitus
/ obesity
