Journal Article

Towards a decision support system for post bariatric hypoglycaemia: development of forecasting algorithms in unrestricted daily-life conditions

Prendin, Francesco, Cappon, Giacomo, Facchinetti, Andrea, Bally, Lia, Streicher, Olivia, Herzig, David, Rolfes, Eva

2025

Overview

Background Post bariatric hypoglycaemic (PBH) is a late complication of weight loss surgery, characterised by critically low blood glucose levels following meal-induced glycaemic excursions. The disabling consequences of PBH underline the need for the development of a decision support system (DSS) that can warn individuals about upcoming PBH events, thus enabling preventive actions to avoid impending episodes. In view of this, we developed various algorithms based on linear and deep learning models to forecast PBH episodes in the short-term. Methods We leveraged a dataset obtained from 50 patients with PBH after Roux-en-Y gastric bypass, monitored for up to 50 days under unrestricted real-life conditions. Algorithms’ performance was assessed by measuring Precision, Recall, F1-score, False-alarms-per-day and Time Gain (TG). Results The run-to-run forecasting algorithm based on recursive autoregressive model (rAR) outperformed the other techniques, achieving Precision of 64.38%, Recall of 84.43%, F1-score of 73.06%, a median TG of 10 min and 1 false alarm every 6 days. More complex deep learning models demonstrated similar median TG but inferior forecasting capabilities with F1-score ranging from 54.88% to 64.10%. Conclusions Real-time forecasting of PBH events using CGM data as a single input imposes high demands on various types of prediction algorithms, with CGM data noise and rapid postprandial glucose dynamics representing the key challenges. In this study, the run-to-run rAR yielded most satisfactory results with accurate PBH event predictive capacity and few false alarms, thereby indicating potential for the development of DSS for people with PBH.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Adult / Algorithms / Analysis / Autoregressive models / Bariatric Surgery - adverse effects / Blood levels / Blood sugar monitoring / Care and treatment / Comorbidity / Complications and side effects / Continuous glucose monitoring / Data-driven forecasting models / Decision support systems / Decision Support Systems, Clinical / Deep Learning / Diabetes / False alarms / Female / Forecasting / Gastric bypass / Gastric Bypass - adverse effects / Gastrointestinal surgery / Glucose / Health aspects / Health Informatics / Humans / Hypoglycemia / Hypoglycemia - diagnosis / Hypoglycemia - etiology / Hypoglycemia - prevention & control / Information Systems and Communication Service / Machine learning / Male / Management of Computing and Information Systems / Medicine / Medicine & Public Health / Middle Aged / Neural networks / Noise prediction / Obesity / Parameter estimation / Post bariatric hypoglycaemia / Prediction Algorithms / Recall / Surgery / Weight control / Weight loss