Asset Details
Do you wish to reserve the book?
Peripheral blood miRNAs are associated with airflow below threshold in children with asthma
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Peripheral blood miRNAs are associated with airflow below threshold in children with asthma
Do you wish to request the book?
Peripheral blood miRNAs are associated with airflow below threshold in children with asthma
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Peripheral blood miRNAs are associated with airflow below threshold in children with asthma
2025
Overview
Background
MicroRNAs (miRNAs) are crucial post-transcriptional regulators involved in inflammatory diseases, such as asthma. Poor lung function and airflow issues in childhood are linked to the development of chronic obstructive pulmonary disease (COPD) in adulthood.
Methods
We analyzed small RNA-Seq data from 365 peripheral whole blood samples from the Genetics of Asthma in Costa Rica Study (GACRS) for association with airflow levels measured by FEV1/FVC. Differentially expressed (DE) miRNAs were identified using DESeq2 in R, adjusting for covariates and applying a 10% false discovery rate (FDR). The analysis included 361 samples and 649 miRNAs. The two DE miRNAs were further tested for association with airflow obstruction in a study of adult former smokers with and without COPD.
Results
We found 1 upregulated and 1 downregulated miRNA in participants with airflow below the threshold compared to those above it. In the adult study, the same miRNAs were upregulated and downregulated in individuals with FEV1/FVC < 0.7 versus those with FEV1/FVC > 0.7, showing suggestive statistical evidence. The target genes of these miRNAs were enriched for PI3K-Akt, Hippo, WNT, MAPK, and focal adhesion pathways.
Conclusions
Two differentially expressed miRNAs were associated with airflow levels in children with asthma and airflow obstruction in adults with COPD. This suggests that shared genetic regulatory systems may influence childhood airflow and contribute to adulthood airflow obstruction.
Publisher
BioMed Central,BioMed Central Ltd,Nature Publishing Group,BMC
Subject
1-Phosphatidylinositol 3-kinase
/ Adult
/ Air flow
/ Asthma
/ Blood
/ Child
/ Children
/ Chronic obstructive pulmonary disease
/ Complications and side effects
/ COPD
/ Female
/ Forced Expiratory Volume - physiology
/ Genetics
/ Humans
/ Male
/ Medicine
/ MicroRNA
/ miRNA
/ miRNAs
/ Pneumology/Respiratory System
/ Pulmonary Disease, Chronic Obstructive - blood
/ Pulmonary Disease, Chronic Obstructive - diagnosis
/ Pulmonary Disease, Chronic Obstructive - epidemiology
/ Pulmonary Disease, Chronic Obstructive - genetics
/ Pulmonary Disease, Chronic Obstructive - physiopathology
/ Smoking
