Journal Article

Quantification of Left Ventricular Torsion and Diastolic Recoil Using Cardiovascular Magnetic Resonance Myocardial Feature Tracking

Hasenfuß, Gerd, Unterberg-Buchwald, Christina, Hussain, Shazia T., Kowallick, Johannes T., Fasshauer, Martin, Lamata, Pablo, Bigalke, Boris, Kutty, Shelby, Sohns, Jan M., Schuster, Andreas, Staab, Wieland, Steinmetz, Michael, Lotz, Joachim

2014

Overview

Cardiovascular magnetic resonance feature tracking (CMR-FT) offers quantification of myocardial deformation from routine cine images. However, data using CMR-FT to quantify left ventricular (LV) torsion and diastolic recoil are not yet available. We therefore sought to evaluate the feasibility and reproducibility of CMR-FT to quantify LV torsion and peak recoil rate using an optimal anatomical approach. Short-axis cine stacks were acquired at rest and during dobutamine stimulation (10 and 20 µg · kg(-1) · min(-1)) in 10 healthy volunteers. Rotational displacement was analysed for all slices. A complete 3D-LV rotational model was developed using linear interpolation between adjacent slices. Torsion was defined as the difference between apical and basal rotation, divided by slice distance. Depending on the distance between the most apical (defined as 0% LV distance) and basal (defined as 100% LV distance) slices, four different models for the calculation of torsion were examined: Model-1 (25-75%), Model-2 (0-100%), Model-3 (25-100%) and Model-4 (0-75%). Analysis included subendocardial, subepicardial and global torsion and recoil rate (mean of subendocardial and subepicardial values). Quantification of torsion and recoil rate was feasible in all subjects. There was no significant difference between the different models at rest. However, only Model-1 (25-75%) discriminated between rest and stress (Global Torsion: 2.7 ± 1.5° cm(-1), 3.6 ± 2.0° cm(-1), 5.1 ± 2.2° cm(-1), p<0.01; Global Recoil Rate: -30.1 ± 11.1° cm(-1) s(-1),-46.9 ± 15.0° cm(-1) s(-1),-68.9 ± 32.3° cm(-1) s(-1), p<0.01; for rest, 10 and 20 µg · kg(-)1 · min(-1) of dobutamine, respectively). Reproducibility was sufficient for all parameters as determined by Bland-Altman analysis, intraclass correlation coefficients and coefficient of variation. CMR-FT based derivation of myocardial torsion and recoil rate is feasible and reproducible at rest and with dobutamine stress. Using an optimal anatomical approach measuring rotation at 25% and 75% apical and basal LV locations allows effective quantification of torsion and recoil dynamics. Application of these new measures of deformation by CMR-FT should next be explored in disease states.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Adult / Algorithms / Biology and Life Sciences / Biomedical engineering / Cardiology / Cardiovascular disease / Coefficient of variation / Correlation analysis / Correlation coefficient / Correlation coefficients / Data processing / Deformation / Diastole - drug effects / Diastole - physiology / Dobutamine - pharmacology / Feasibility studies / Female / Fourier analysis / Heart / Heart failure / Hemodynamics - drug effects / Hospitals / Humans / Interpolation / Magnetic resonance / Magnetic Resonance Imaging, Cine / Male / Medicine and Health Sciences / Middle Aged / Myocardium - metabolism / NMR / Nuclear magnetic resonance / Recoil / Reproducibility / Resonance / Rest / Rotation / Three dimensional models / Torsion / Torsion, Mechanical / Ventricle / Ventricular Function, Left - drug effects / Ventricular Function, Left - physiology / Young Adult