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FDG-avid pulmonary mucous gland adenoma mimicking lung cancer on 18 F-FDG PET/CT: a rare case report and literature review
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FDG-avid pulmonary mucous gland adenoma mimicking lung cancer on 18 F-FDG PET/CT: a rare case report and literature review
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Journal Article
FDG-avid pulmonary mucous gland adenoma mimicking lung cancer on 18 F-FDG PET/CT: a rare case report and literature review
2025
Overview
Background
Pulmonary mucous gland adenoma (MGA) is an exceptionally rare benign tumor. Even with the assistance of 18 F-FDG PET/CT, the accurate diagnosis of MGA as lung cancer remains challenging. Only one case of fluorodeoxyglucose(FDG)-avid pulmonary mucous gland adenoma and two case of low FDG uptake pulmonary mucous gland adenoma have been reported in English literature, while a single case of moderately increased FDG uptake pulmonary mucous gland adenoma has been documented in French literature. To minimize misdiagnosis and select appropriate treatment strategies, it is crucial to comprehensively analyze its 18 F-FDG PET/CT manifestations in conjunction with clinical symptoms and pathological findings.
Case presentation
In our study, we present a case involving a 70-year-old woman with clinical manifestations of persistent cough and sputum with an FDG-avid mucous gland adenoma mimicking lung cancer on 18 F-FDG PET/CT imaging. Ultimately, the patient underwent a potentially unnecessary video-assisted thoracoscopic lobectomy, and the pathological diagnosis was determined to be MGA. The patient was discharged and remained clinically well without any complaints for a period of 6 months.
Conclusions
The use of 18 F-FDG PET/CT lacks specificity in detecting MGA and may lead to misdiagnosis as a lung malignancy. A comprehensive analysis combining clinical manifestations, bronchoscopy findings, imaging results, and pathological findings is essential for accurate identification of pulmonary mucus gland adenoma.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Adenoma
/ Adenoma - diagnostic imaging
/ Aged
/ Analysis
/ Biopsy
/ Cough
/ Female
/ Glands
/ Humans
/ Hypoxia
/ Lung Neoplasms - diagnostic imaging
/ Medicine
/ Mimicry
/ Ostomy
/ Patients
/ Pneumology/Respiratory System
/ Positron emission tomography
/ Positron Emission Tomography Computed Tomography
/ Pulmonary mucous gland adenoma
/ Radiomics approaches to lung cancers
/ Sputum
/ Tumors
