Journal Article

Clinical characteristics and outcomes of patients with Corona Virus Disease 2019 (COVID-19) at Mercy Health Hospitals, Toledo, Ohio

Sandho, Gaurav, Avasthi, Salil, Khan, Muhammad Shayan, Kumar, Aakash, Salman, F. N. U., Sood, Divya, Dogra, Ratika, Jacob, Karim, Mahajan, Vijay, Auoad, Arlette, Miriyala, Leela K. V., Ishtiaq, Rizwan, Luthra, Kritika, Sharma, Ravina, Patti, Dilnoor K., Edara, Dharmakaruna, Pittampalli, Shanti, Khatri, Vinod, Katragadda, Srinivas, Ravikumar, Rekha

2021

Overview

The ongoing pandemic of the novel Corona Virus Disease 2019 (COVID-19) is an unprecedented challenge to global health, never experienced before. This study aims to describe the clinical characteristics and outcomes of patients with COVID-19 admitted to Mercy Hospitals. Retrospective, observational cohort study designed to include every COVID-19 subject aged 18 years or older admitted to Mercy Saint (St) Vincent, Mercy St Charles, and Mercy St Anne's hospital in Toledo, Ohio from January 1, 2020 through June 15th, 2020. Primary Outcome Measure was mortality in the emergency department or as an in-patient. 470 subjects including 224 males and 246 females met the inclusion criteria for the study. Subjects with the following characteristics had higher odds (OR) of death: Older age [OR 8.3 (95% CI 1.1-63.1, p = 0.04)] for subjects age 70 or more compared to subjects age 18-29); Hypertension [OR 3.6 (95% CI 1.6-7.8, p = 0.001)]; Diabetes [OR 3.1 (95% CI 1.7-5.6, p<0.001)]; COPD [OR 3.4 (95% CI 1.8-6.3, p<0.001)] and CKD stage 2 or greater [OR 2.5 (95% CI 1.3-4.9, p = 0.006)]. Combining all age groups, subjects with hypertension had significantly greater odds of the following adverse outcomes: requiring hospital admission (OR 2.2, 95% CI 1.4-3.4, p<0.001); needing respiratory support in 24 hours (OR 2.5, 95% CI: 1.7-3.7, p<0.001); ICU admission (OR 2.7, 95% CI 1.7-4.4, p<0.001); and death (OR 3.6, 95% CI 1.6-7.8, p = 0.001). Hypertension was not associated with needing vent in 24 hours (p = 0.07). Age and hypertension were associated with significant comorbidity and mortality in Covid-19 Positive patients. Furthermore, people who were older than 70, and had hypertension, diabetes, COPD, or CKD had higher odds of dying from the disease as compared to patients who hadn't. Subjects with hypertension also had significantly greater odds of other adverse outcomes.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Adolescent / Adult / Age / Age Factors / Age groups / Aged / Biology and Life Sciences / Comorbidity / Complications and side effects / Corona / Coronaviruses / COVID-19 / COVID-19 - diagnosis / COVID-19 - epidemiology / COVID-19 - mortality / COVID-19 - therapy / Critical care / Data analysis / Demographic aspects / Diabetes / Diabetes Mellitus - epidemiology / Disease / Drafting software / Editing / Epidemics / Epidemiology / Female / Global health / Health care facilities / Hospital Mortality / Hospitals / Humans / Hypertension / Hypertension - epidemiology / Infectious diseases / Intensive Care Units / Internal medicine / Male / Medicine / Medicine and Health Sciences / Methodology / Middle Aged / Middle East respiratory syndrome / Morbidity / Mortality / Ohio - epidemiology / Pandemics / Patient outcomes / Patients / People and Places / Physiological aspects / Public health / Pulmonary Disease, Chronic Obstructive - epidemiology / Renal Insufficiency, Chronic - epidemiology / Respiratory diseases / Retrospective Studies / Risk Factors / SARS-CoV-2 - isolation & purification / Severe acute respiratory syndrome coronavirus 2 / United States / Viral diseases / Viruses / Visualization / Young Adult