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Dragon 1 Protocol Manuscript: Training, Accreditation, Implementation and Safety Evaluation of Portal and Hepatic Vein Embolization (PVE/HVE) to Accelerate Future Liver Remnant (FLR) Hypertrophy

by Chang, D. H , Meijerink, M. R , Fundora, Y , Fondevila, C , Grünberger, T , Moelker, A , Qu, X , Kingham, T. P , Kalff, J. C , Erdmann, J. I , Montanari, N , Peddu, P , Mehrabi, A , Kazemier, G , Bruijnen, R. C. G , Nguyen, J , Leclercq, W. K. G , Camacho, J. C , Hilal, M. Abu , Fretland, Å , Delle, M , White, S. A , Primrose, J. N , Valenti, D , Font, J. Codina , Hess, G. F , Arslan, B , Ben, S. Lopez , Martel, G , Metrakos, P , Gérard, L , choi, J , Ratti, F , van Baardewijk, L. J , Imani, F , Gobardhan, P. D , Cugat, E , Borobia, F. Garcia , Heil, J , Neumann, U. P , Díaz-Nieto, R , MacDonald, A , Binkert, C. A , Herrero, E , Sutcliffe, R. P , Breitenstein, S , Grünhagen, D. J , Moragues, J. Sampere , van der Leij, C , Zijlstra, I. A. J , Bokkers, R. P. H , De Boo, D. W , Kleeff, J , Ahle, M , Hagendoorn, J , Guitart, J , Udupa, V , Dili, A , Aldrighetti, L. A , Chan, B. K. Y , Madoff, D. C , Wang, X , Björnsson, B , Büchler, M. W , Modi, S , Vogl, T. J , Korenblik, R , Bruners, P , Hoffmann, M. H , Bemelmans, M. H. A , Lucidi, V , Serenari, M , Stavrou, G. A , Gómez, F , Ronellenfitsch, U , Davis, R , Navines, J , Tasse, J. C , Gelabert, A , Yu, D , Heise, D , Serrablo, A , de Boer, M. T , Carling, U , Jovine, E , Sandström, P , Mehrz

in Colorectal cancer / Colorectal carcinoma / Embolization / Hepatic vein / Hypertrophy / Liver / Liver cancer / Metastases / Safety / Survival

2022

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Dragon 1 Protocol Manuscript: Training, Accreditation, Implementation and Safety Evaluation of Portal and Hepatic Vein Embolization (PVE/HVE) to Accelerate Future Liver Remnant (FLR) Hypertrophy

in Colorectal cancer / Colorectal carcinoma / Embolization / Hepatic vein / Hypertrophy / Liver / Liver cancer / Metastases / Safety / Survival

2022

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Dragon 1 Protocol Manuscript: Training, Accreditation, Implementation and Safety Evaluation of Portal and Hepatic Vein Embolization (PVE/HVE) to Accelerate Future Liver Remnant (FLR) Hypertrophy

in Colorectal cancer / Colorectal carcinoma / Embolization / Hepatic vein / Hypertrophy / Liver / Liver cancer / Metastases / Safety / Survival

2022

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Journal Article

Dragon 1 Protocol Manuscript: Training, Accreditation, Implementation and Safety Evaluation of Portal and Hepatic Vein Embolization (PVE/HVE) to Accelerate Future Liver Remnant (FLR) Hypertrophy

Chang, D. H,

Meijerink, M. R,

Fundora, Y,

Fondevila, C,

Grünberger, T,

Moelker, A,

Qu, X,

Kingham, T. P,

Kalff, J. C,

Erdmann, J. I,

Montanari, N,

Peddu, P,

Mehrabi, A,

Kazemier, G,

Bruijnen, R. C. G,

Nguyen, J,

Leclercq, W. K. G,

Camacho, J. C,

Hilal, M. Abu,

Fretland, Å,

Delle, M,

White, S. A,

Primrose, J. N,

Valenti, D,

Font, J. Codina,

Hess, G. F,

Arslan, B,

Ben, S. Lopez,

Martel, G,

Metrakos, P,

Gérard, L,

choi, J,

Ratti, F,

van Baardewijk, L. J,

Imani, F,

Gobardhan, P. D,

Cugat, E,

Borobia, F. Garcia,

Heil, J,

Neumann, U. P,

Díaz-Nieto, R,

MacDonald, A,

Binkert, C. A,

Herrero, E,

Sutcliffe, R. P,

Breitenstein, S,

Grünhagen, D. J,

Moragues, J. Sampere,

van der Leij, C,

Zijlstra, I. A. J,

Bokkers, R. P. H,

De Boo, D. W,

Kleeff, J,

Ahle, M,

Hagendoorn, J,

Guitart, J,

Udupa, V,

Dili, A,

Aldrighetti, L. A,

Chan, B. K. Y,

Madoff, D. C,

Wang, X,

Björnsson, B,

Büchler, M. W,

Modi, S,

Vogl, T. J,

Korenblik, R,

Bruners, P,

Hoffmann, M. H,

Bemelmans, M. H. A,

Lucidi, V,

Serenari, M,

Stavrou, G. A,

Gómez, F,

Ronellenfitsch, U,

Davis, R,

Navines, J,

Tasse, J. C,

Gelabert, A,

Yu, D,

Heise, D,

Serrablo, A,

de Boer, M. T,

Carling, U,

Jovine, E,

Sandström, P,

Mehrz

2022

Overview

Study PurposeThe DRAGON 1 trial aims to assess training, implementation, safety and feasibility of combined portal- and hepatic-vein embolization (PVE/HVE) to accelerate future liver remnant (FLR) hypertrophy in patients with borderline resectable colorectal cancer liver metastases.MethodsThe DRAGON 1 trial is a worldwide multicenter prospective single arm trial. The primary endpoint is a composite of the safety of PVE/HVE, 90-day mortality, and one year accrual monitoring of each participating center. Secondary endpoints include: feasibility of resection, the used PVE and HVE techniques, FLR-hypertrophy, liver function (subset of centers), overall survival, and disease-free survival. All complications after the PVE/HVE procedure are documented. Liver volumes will be measured at week 1 and if applicable at week 3 and 6 after PVE/HVE and follow-up visits will be held at 1, 3, 6, and 12 months after the resection.ResultsNot applicable.ConclusionDRAGON 1 is a prospective trial to assess the safety and feasibility of PVE/HVE. Participating study centers will be trained, and procedures standardized using Work Instructions (WI) to prepare for the DRAGON 2 randomized controlled trial. Outcomes should reveal the accrual potential of centers, safety profile of combined PVE/HVE and the effect of FLR-hypertrophy induction by PVE/HVE in patients with CRLM and a small FLR.Trial RegistrationClinicaltrials.gov: NCT04272931 (February 17, 2020). Toestingonline.nl: NL71535.068.19 (September 20, 2019).

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Springer Nature B.V

Subject

Colorectal cancer

/ Colorectal carcinoma

/ Liver