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Risk-reducing surgery increases survival in BRCA1/2 mutation carriers unaffected at time of family referral
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Risk-reducing surgery increases survival in BRCA1/2 mutation carriers unaffected at time of family referral
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Journal Article
Risk-reducing surgery increases survival in BRCA1/2 mutation carriers unaffected at time of family referral
2013
Overview
The aim of this study was to establish if risk-reducing surgery (RRS) increases survival among
BRCA1
/
2
carriers without breast/ovarian cancer at the time of family referral. Female
BRCA1/2
carriers were identified from the Manchester Genetic Medicine Database. Those patients alive and unaffected at the date of first family ascertainment were included in this study. Female first-degree relatives (FDRs) without predictive genetic testing who otherwise met eligibility criteria were also included. The effect of breast and ovarian RRS on survival was analysed. The survival experiences of RRS and non-RRS patients, stratified by
BRCA
status, were examined with Kaplan–Meier curves and contrasted using log-rank tests and Cox models. 691 female
BRCA1/2
mutation carriers without breast or ovarian cancer at time of family ascertainment were identified; 346
BRCA1
and 345
BRCA2
. 105
BRCA1
carriers and 122
BRCA2
carriers developed breast cancer during follow-up. The hazard of death was statistically significantly lower (
P
< 0.001) following RRS versus no RRS. 10-year survival for women having RRS was 98.9 % (92.4–99.8 %) among
BRCA1
and 98.0 % (92.2–99.5 %) among
BRCA2
carriers. This survival benefit with RRS remained significant after FDRs were added. Women who had any form of RRS had increased survival compared to those who did not have RRS; a further increase in survival was seen among women who had both types of surgery. However, formal evidence for a survival advantage from bilateral mastectomy alone requires further research.
Publisher
Springer US,Springer,Springer Nature B.V
Subject
/ Adult
/ Aged
/ Biological and medical sciences
/ Breast Neoplasms - mortality
/ Child
/ Female
/ Genetics
/ Gynecology. Andrology. Obstetrics
/ Humans
/ Medicine
/ Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
/ Mutation
/ Oncology
/ Ovarian Neoplasms - genetics
/ Ovarian Neoplasms - mortality
/ Surgery
/ Tumors
