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Effect of exercise on telomere length and telomere proteins expression in mdx mice

by Licata, Norma , Oteri Rosaria , Romeo, Sara , Messina, Sonia , Mantuano Paola , Vita Giuseppe , Bonanno, Carmen , Aguennouz M’hammed , Sanarica Francesca , Nicocia Giulia , Vita Gian Luca , Polito, Francesca , De, Luca Annamaria , Distefano, Maria Grazia , Sframeli, Maria , La Rosa Matteo

in Adenosine diphosphate / Animal models / Animals / Biotechnology / Cells (biology) / Deregulation / Diaphragm / Duchenne's muscular dystrophy / Dystrophy / Fitness equipment / Genotype & phenotype / Membranes / Muscles / Muscular dystrophy / Musculoskeletal system / Oxidative stress / Peptides / Poly(ADP-ribose) polymerase / Polyclonal antibodies / Proteins / Ribose / RNA-directed DNA polymerase / Rodents / Satellite cells / Senescence / Skeletal muscle / Statistical analysis / Telomerase / Telomerase reverse transcriptase / Telomeres / Yeast

2020

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Effect of exercise on telomere length and telomere proteins expression in mdx mice

2020

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Effect of exercise on telomere length and telomere proteins expression in mdx mice

2020

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Journal Article

Effect of exercise on telomere length and telomere proteins expression in mdx mice

Licata, Norma,

Oteri Rosaria,

Romeo, Sara,

Messina, Sonia,

Mantuano Paola,

Vita Giuseppe,

Bonanno, Carmen,

Aguennouz M’hammed,

Sanarica Francesca,

Nicocia Giulia,

Vita Gian Luca,

Polito, Francesca,

De, Luca Annamaria,

Distefano, Maria Grazia,

Sframeli, Maria,

La Rosa Matteo

2020

Overview

In Duchenne muscular dystrophy (DMD), telomere shortening has been postulated to contribute to the failure of regenerative activity promoting the premature senescence of satellite cells. The aim of the present study was to investigate the telomere length and the expression of telomeric repeat-binding factor-1 (TRF1), poly (ADP-ribose) polymerase-1 (PARP1) and mouse telomerase reverse transcriptase (MTERT) in gastrocnemius, tibialis anterior and diaphragm muscles of the murine model of DMD, the mdx mouse and whether a chronic protocol of forced exercise impacts on them. Our results confirmed a telomere shortening in mdx muscles, more evident in the diaphragm, in which exercise induced a greater shortening than in wild-type mice. Moreover, we showed for the first time in mdx an increased TRF1 and PARP1 expression and an augmented activity of MTERT, further enhanced by exercise. These results reinforce the hypothesis that a deregulation of mechanisms involved in telomere length occurs and may pave the way for the test of compounds targeting proteins modulating telomere maintenance as a novel strategy to treat dystrophinopathies.

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Publisher

Springer Nature B.V

Subject

Adenosine diphosphate

/ Animals